Reaction conditions optimization for the Suzuki reaction on 2-bromoacetophenone
Reaction for the Suzuki reaction on 2-bromoacetophenone
Entry
Catalyst
Solvent
Temperature
Time (h)
Yield (%)
1
Pd(OAc)2 + PPh3a
Toluene
Reflux
16
65
2
PdCl2b
Toluene
Reflux
16
65
3
Pd(PPh3)4b
Toluene
Reflux
16
80
4
Pd(PPh3)4b
20% EtOH:H2O
Reflux
3
90
5
Pd(PPh3)4b
50% EtOH:H2O
Reflux
3
93
6
Pd(PPh3)4b
H2O
Reflux
3
92
7
Pd(PPh3)4b
-
200°C
3
70
8
Pd(PPh3)4c
H2O
Reflux
3
95
9
Pd(PPh3)4d
H2O
Reflux
3
60
10
Pd(PPh3)4c, e
H2O
Reflux
3
87
a Catalyst: 10 mol% and 20 mol% respectively. b Catalyst: 10 mol%. c Catalyst: 5 mol%. d Catalyst: 1 mol%. e Scale up to 10 mmol from 0.2 mmol. -: no solvent
DCZ: Writing—original draft, Investigation, Data curation. MFMFA: Writing—review & editing, Investigation, Data curation. MSR and RdSB: Investigation. JdBVN: Writing—original draft, Investigation. CdÓP: Validation, Supervision, Funding acquisition. CDB: Conceptualization, Validation, Writing—review & editing, Supervision, Funding acquisition. All authors read and approved the submitted version.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher.
Funding
This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brazil (CAPES)-Finance Code 001, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for the scholarships and Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), process number [E-26/202.780/2019], and the National Program for Oncological Care PRONON/NUP [25000.019172/2021-11]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
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