IC50 values (µM) of biaryl hydroxy-triazoles and fluorene-triazoles compounds across a panel of human cell lines after 72 h exposure
Compound
Cell lines
HCT-116
SNB-19
MDA-MB-231
MOLM-13
HEK-293
LSO258
> 50
> 50
> 50
25.5
> 50
LSO272
> 50
> 50
> 50
12.5
34.5
LSO276
> 50
> 50
> 50
24.8
42.6
LSO278
23.4
> 50
34.3
18.7
20.8
LSO281
28.2
> 50
> 50
22.7
24.7
Doxorubicin
ND
0.8
0.2
ND
0.8
5-Fluorouracil
19.2
ND
ND
ND
6.9
Azacitidine
ND
ND
ND
0.99
> 50
> 50: not able to determine the half-maximal inhibitory concentration (IC50) value within the range of concentration tested for this cell line. ND: not determined
DCZ: Writing—original draft, Investigation, Data curation. MFMFA: Writing—review & editing, Investigation, Data curation. MSR and RdSB: Investigation. JdBVN: Writing—original draft, Investigation. CdÓP: Validation, Supervision, Funding acquisition. CDB: Conceptualization, Validation, Writing—review & editing, Supervision, Funding acquisition. All authors read and approved the submitted version.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher.
Funding
This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brazil (CAPES)-Finance Code 001, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for the scholarships and Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), process number [E-26/202.780/2019], and the National Program for Oncological Care PRONON/NUP [25000.019172/2021-11]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
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