List of the most potent phytocomponents inhibiting 3CLpro

PhytocomponentIC50 (μmol/L)ReferencesScoring function (kcal/mol)References
Epicatechin gallate1.58[13]–8.2[22]
CCG 50014*0.23; 0.15[13]NANA
Baicalein0.02; 0.94[13]–7.3[23]
Dihydromyricetin0.18[13]–6.2[24]
Hematoxylin0.22[13]NA[25]
Schaftoside1.73[15]–8.4[26]
Sennoside A1.59[13]–8.6[27]

*: also known as 4-(4-fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione. NA: not available