Need for artificial ventilation, length of stay in intensive care, and mortality
Ivermectin + colchicine + standard care—45; colchicine + standard care—45; standard care—45
Colchicine was associated with clinically significant reductions in oxygen demand days, intensive care unit length of stay, and less mortality, while ivermectin added no beneficial effect.
Need for artificial lung ventilation, length of stay intensive therapy, mortality
40/40
Serum ferritin levels in most patients who received colchicine, returned to normal in contrast to the control group, whose serum ferritin levels remained high. Similarly, the mean CRP and D-dimer values after treatment among participants in the colchicine group were significantly lower than in the control group. Patients in the colchicine group stayed in the hospital for a shorter period compared with the control group.
Need for artificial lung ventilation, length of stay in intensive care, mortality
36/36
Colchicine reduced the duration of additional oxygen therapy and hospitalization. The drug was well tolerated. Since death was a rare event, one cannot argue that colchicine reduced COVID-19 mortality.
AK: Data curation, Visualization, Writing—original draft. NI: Data curation, Writing—original draft. IG and VP: Conceptualization, Supervision.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
Not applicable.
Funding
The study is performed in the framework of the Program for Basic Research in the Russian Federation for a long-term period (2021–2030) project No. [121102900156-6]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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