Table Info

Table 1.

The comparison properties of three classes of therapeutic molecules

Properties	Small molecules	Stapled peptides	Biologics
Molecular weight	< 1,000	1,000–5,000	> 10,000
Stability	High	High	Low
Binding affinity	Low	High	High
Specificity	Low	High	High
Cellular permeability	High	High	Low
Proteolysis resistance	High	High	Low
Toxicity/side effects	High	Low	Low
Ability to disrupt PPIs	Low	High	High
Manufacturing cost	Low	Low	High

Declarations

Author contributions

QZ and ZW equally contributed to: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. XM: Investigation, Writing—review & editing. QC: Validation, Writing—review & editing, Supervision. CZ: Conceptualization, Writing—original draft, Writing—review & editing, Supervision.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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