Calculated potential energy of interaction (ΔE) and free energy of hydration (ΔG) for the interaction of fluevirines with the tubulin dimer

CompoundsΔE (kcal/mol)ΔG (kcal/mol)
Securinine–44.60–17.10
Norsecurinine–44.20–17.10
Fluevirine A–73.90–20.90
Fluevirine B–49.30–20.90
Fluevirine C–52.20–14.90
Fluevirine D–47.70–16.85
Fluevirine E–56.85–24.50
Fluevirine F–50.20–12.90