Summary of autophagy inducers (AI) and senescence inhibitors (SI) along with their potential target mechanisms

CompoundsTarget/mechanismReferences
AIResveratrolSirtuin-1[53]
QuercetinRas-Raf signaling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signaling, and p53[26]
Plant lectinRas-Raf signaling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signaling, and p53[26]
TrehaloseAntioxidant and more[54]
Cyclo-trijuglone of Juglans regia L.Inhibitor of mTOR[12]
ResveratrolRas-Raf signaling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signaling, and p53[26]
PaclitaxelRas-Raf signaling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signaling, and p53[26]
OridoninRas-Raf signaling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signaling, and p53[26]
SICurcuminAnti-inflammatory, immune-regulatory, anti-oxidative, and lipid-modifying properties[55]
QuercetinSelectively clear senescent cells; reduce senescence-associated secretory phenotype (SASP); Ras-Raf signaling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signaling, and p53[26]
FisetinSelectively clear senescent cells; reduce SASP[8, 14]
DasatinibSelectively clear senescent cells[8]
NavitoclaxSelectively clear senescent cells[8]