Table Info

Table 2.

Partition coefficients (logP) values for lysine (Lys) and acetyllysine [(Ac)Lys] using the capping groups of the Model 1 and change in lipophilicity due to acetylation (ΔlogP_Ac) of lysine residues

Amino acid code	Lipophilicity		ΔlogP_Ac
Amino acid code	Lys (logD₂)	(Ac)Lys (logP)	ΔlogP_Ac
This work	–3.07	–1.64	1.43
ChemAxon	–4.51	–1.66	2.85
milogP	–3.73	–1.25	2.48

Supplementary materials

The supplementary materials for this article are available at: https://www.explorationpub.com/uploads/Article/file/100853_sup_1.pdf.

Declarations

Author contributions

AV and WJZ: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing—original draft, Writing—review & editing. PM and DBR: Investigation, Data curation, Visualization, Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

The datasets generated and/or analyzed for this study can be found in the NSAAs-Lipophilicity Github repository: https://github.com/tviayna/NSAAs-Lipophilicity.

Funding

The authors thank the Spanish Ministerio de Ciencia e Innovación [PID2020-117646RB-I00, MCIN/AEI/10.13039/501100011033], Generalitat de Catalunya [2021SGR00671], and Consorci de Serveis Universitaris de Catalunya [CSUC; Molecular Recognition project] for financial support. The authors thank the Vice Chancellor for Research of the University of Costa Rica for its support work via the research project [115-C1-450]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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