Table Info

Table 2.

Types of leishmanial vaccines and their mechanism of action [87–98]

Name of vaccine	Essential component/antigen	Adjuvant and their mechanism of action
Leishvaccine	Whole-killed promastigotes of L. amazonensis	BCG (Bacillus Calmette Guerin); CD4+, CD8+, B cell activation
ALM^ϼ (autoclaved-killed L. major)	Autoclave-killed L. major	BCG; T cell activation
Leishmune	FML (fucose-mannose ligand)	Saponin; T cell activation
CaniLeish	LiESP (L. infantum excreted-secreted protein)	Saponin; induction of Th1 cell
GALM^α (gentamycin-attenuated L. major)	GALM	T and B cell activation
LEISH-F1	TSA + LmSTI1 + LeIF	MPL-SE (monophosphoryl lipid A-stable emulsion); T cell activation
LEISH-F2	LEISH-F2, designed from LEISH-F1	MPL-SE; T cell activation
LEISH-F3	NH + SMT (nucleoside hydrolase; sterol 24-c-methyltransferase)	GLA (glucopyranosyl lipid A)-SE; T cell activation
Leish-Tec	L. donovani A2 protein	Saponin; T cell activation
SMT^γ + NH^μ	NH + SMT	GLA-SE; T cell activation
ChAd63-KH	KMP-11 + HASPB (kinetoplastid membrane protein 11; hydrophilic acylated surface protein B)	Broad CD8+ T cell activation

Declarations

Acknowledgments

I acknowledge the esteemed faculty and researchers at Bharati Vidyapeeth (Deemed to be University) Poona College of Pharmacy, Pune for their valuable contributions and support in the development of this review article. Their expertise and guidance have been instrumental in shaping the content and insights presented in this work. I extend my sincere gratitude to the institution for providing a conducive academic environment that fosters research excellence and innovation.

Author contributions

TM: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing—original draft, Writing—review & editing. DK and DB: Formal analysis, Project administration, Supervision, Visualization, Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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