Table Info

Table 3.

Epitopes identified in Latin American scorpion toxins

Venom animal	Toxin (UniProt)	Epitope peptide	Epitope mapping	Immunogen	Reference
Tityus serrulatus	Ts3 (P01496)	L⁵⁰PDSEPTKTNGKCKS⁶⁴	Spot synthesis	Peptide bound to KLH	[36]
Tityus serrulatus	Ts4 (O77463)	G¹REGYPADSKGCKIT¹⁵, T²⁹LKKGSSGYCAWPAC⁴³, P⁴⁹DSVKIWTSETNKCG⁶³	Spot synthesis	Peptide bound to KLH	[36]
Tityus serrulatus	Ts1 (P15226)	K¹EGYLMDHEGSKLSSAGC¹⁵, I¹⁷RPSGYSGRESGIKKAGC³¹, L⁴⁷PNWVKVWDRATNKAGC⁶¹	Spot synthesis	Peptide bound to KLH	[37]
	Ts2 (P68410)	K¹EGYAMDHEGSKFSSAGC¹⁵, V⁴⁸PDHIKVWDYATNKSAGC⁶²
	Ts3 (P01496)	K¹KDGYPVEYDNSAYIAGC¹⁵, W¹⁶NAYSDKLSKDKAGC³⁰, G⁴⁸LPDSEPTKTNGKSKAGC⁶²
Tityus serrulatus	Ts4 (O77463)	G¹REGYPAD⁸-GG-G⁴⁷LPDSVKI⁵⁴	Spot synthesis	Peptide bound to OVA	[38]
Tityus trivittatus	Tt1g (P0DMM8)	LPNWVKVWERATNR-Abu	Informatic	Branched or palmitoylated peptide	[53]

Abu: α-aminobutyric acid; KLH: keyhole limpet hemocyanin; OVA: ovalbumin

Declarations

Author contributions

JAR, GRBV, and JAE: Writing—original draft, Writing—review & editing. SAC: Funding acquisition, Conceptualization, Writing—original draft, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This work was partially supported by the Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación de la República Argentina [PICT-2021-I-A-00236]; the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) [PIP 11220210100075CO] and the Universidad de Buenos Aires, Argentina [20020220200001BA]. SAC is a researcher at the CONICET and a professor at the UBA. JAR, GRBV, and JAE are teachers at the UBA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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