Epitopes identified in Latin American spider toxins

Venom animalToxin (UniProt)Peptide epitopeEpitope mappingImmunogenReference
Loxosceles intermediaLiD1 (P0CE81)M13VNAIGQIDEFVNLG27, I31ETDVSFDDNANPEY45, S58KKYENFNDFLKGLR72, D100NQANDAGKKLAKNL114, D160KVGHDFSGNDDISD174, N247YPDVITDVLNEAAY261Spot synthesisPeptide mixture with or without rLiD1[39]
Loxosceles intermediaLiD1 (P0CE81)N25LGANSIETDVSFDDNANPEYTYHGIP51Spot synthesisPeptide[40]
Loxosceles intermediaLiD1 (P0CE81)NCNKNDHLFACW, NSNKNDHLFASWPhage displayPeptide in liposomes[45]
Phoneutria nigriventerδ-ctenitoxin-Pn2a (P29425)GYFWIAWYKLAN-Abu-KKGInformaticBranched or palmitoylated peptide[22]

Abu: α-aminobutyric acid; LiD1: Loxosceles intermedia dermonecrotic protein 1; rLiD1: recombinant Loxosceles intermedia dermonecrotic protein 1