Predicted and observed absolute bioavailability in children

MedicinesAgeObserved F mean (%)Observed range (%)Predicted F (%)Ratio of predicted/observedReferences
MidazolamAdult4832–64NANA[8]
Preterm4912–100380.77[9, 10]
0.5–2 years37±21421.14[11]
5.5–6 years27NA421.57[12]
FamotidineAdult4538–51NANA[13]
11–15 years51NA450.88[14]
0–1 year42NA451.07[15]
VoriconazoleAdult8375–94NANA[16]
2–<6 years44NA791.79[17]
6–<12 years91NA790.86[17]
DiclofenacAdult54NANANA[18]
1–12 years70NA600.85[19, 20]
CyclosporineAdult22±7.4NANA[21]
1.1–2.5 years2211–35190.86[22]
CefetametAdult4124–64NANA[23]
3–7 years4929–70390.79[24]
>7–12 years3836–47391.02[24]
3.5–17.3 months38±19391.02[25]
ZidovudineAdult7560–95NANA[26]
Term < 14 days89±19750.84[27]
Term > 14 days61±19751.23[27]
AzithromycinAdult43±13NANA[28]
0.5–2 years27NA391.43[29, 30]
>2–5 years37NA451.20[29, 30]
7–12 years52NA450.86[29–31]
BusulfanAdult8047–103NANA[32]
1.4–6 years6822–120731.07[32]
CimetidineAdult6030–100NANA[33]
4–13 years5451–57591.09[34]
DigoxinAdult7463–84NANA[35]
Newborn infants7252–79731.02[36]
ClonidineAdult88±9NANA[37]
3–10 years55NA881.62[38]
RanitidineAdult5135–65NANA[39]
3.5–16 years4822–96460.95[40]
KetoprofenAdult≥92NANANA[41]
7–93 months77NA921.20[42, 43]
0.5–2 years80NA921.15[42–44]
>2–7 years69NA921.34[42–44]
ItraconazoleAdult19NANANA[45, 46]
0.5–2 years32NA200.63[47, 48]
>2–5 years35NA220.62[47, 48]
>5–12 years30NA220.73[47, 48]

F: absolute bioavailability; NA: not available