Table Info

Table 3.

Summary of bivalent second mitochondria-derived activator of caspases (SMAC) mimetics. Bivalent SMAC mimetics in clinical trials and bivalent SMAC mimetics are presented in literature but not discussed in this review

Compound	Cancer type	Clinical trials	References
Birinapant^※	Acute myelogenous leukaemia	NCT01486784	[128]
APG-1387^※	Nasopharyngeal carcinoma	NCT03386526	[140]
Compound 9a	Breast cancer	-	[141]
Compound 3	Leukaemia	-	[133]
BV6	Rhabdomyosarcoma	-	[142]
SM-164	Leukaemia	-	[143]
AEG40730	Ovarian	-	[144]
Compound A	Ovarian	-	[145]
Compound 3	Human glioblastoma	-	[146]
SMAC14-2X	Breast cancer	-	[147]
SMAC17-2X	Breast cancer	-	[147]
Compound 9a	Breast cancer	-	[148]

^※ Drugs in clinical trial for different cancer types; -: no data

Declarations

Author contributions

AV and RDM: Conceptualization, Validation, Writing—original draft, Writing—review & editing, Supervision. DL: Validation, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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