Table Info

Table 2.

Total number of CRAC/CARC motifs identified in the primary structure of RTX toxins [60]

RTX toxin	Bacterium	CRAC motif	CARC motif
EhxA	Enterohemorrhagic (EHEC) Escherichia coli	16	15
LktA	Mannheimia haemolytica	15	13
PILktA	Mannheimia varigena	21	16
PaxA	Pasteurella aerogenes	19	21
MmxA	Morganella morganii	13	15
HlyA	UPEC	13^*	13
CyaA	Bordetella pertussis	22	18
LtxA	Aggregatibacter actinomycetemcomitans	24	20
ApxIA	Actinobacillus pleuropneumoniae	18	16
ApxIIA	A. pleuropneumoniae	16	16
ApxIIIA	A. pleuropneumoniae	22	19
MbxA	Moraxella bovis	25	18
RtxA	Kingella kingae	12	14

* The differences observed from results published by Vazquez et al. [52] are due to the flexibility impair to the sequence of the CRAC domain. CRAC: cholesterol recognition/interaction amino acid consensus; RTX: Repeat in ToXins; HlyA: alpha-hemolysin; UPEC: uropathogenic Escherichia coli; LtxA: leukotoxin. Adapted from [60]. © 2024 by the authors. CC BY

Declarations

Acknowledgments

The author thanks Mario Ramos for the graphical designs.

Author contributions

VH: Conceptualization, Investigation, Writing—review & editing, Writing—original draft.

Conflicts of interest

The author declares that there are no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This work was supported by Fundación Florencio Fiorini Grant [2023-2024] and by Universidad Nacional de La Plata (UNLP) Grant number [M247]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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