List of semi-synthetic antibacterial agents with their mechanisms of action

Semi-synthetic antibacterialsMechanism of actionReference
CeftarolineBinds to penicillin-binding proteins, disrupts cell wall synthesis and cross-linking, leading to weakened cell walls, bacterial lysis, and cell death.[39]
DalbavancinInhibits bacterial cell wall synthesis by binding to the D-alanyl-D-alanine terminus of peptidoglycan chains, disrupting transpeptidation, which results in a weakened cell wall and bacterial lysis.[40]
OritavancinUtilizes three mechanisms: i) inhibition of transglycosylation, ii) inhibition of transpeptidation, and iii) disruption of bacterial cell membrane.[41]