Comparison between minimal and whole body PBPK prediction for AUC
Range
mPBPK
Whole body PBPK
Within the range #
Within the range (%)
Within the range #
Within the range (%)
Mild (n = 19)
0.5–2
16
84
17
89
0.5–1.5
15
79
14
74
0.7–1.3
11
58
10
53
> 2
0
0
1
5
< 0.5
3
16
1
5
AFE
0.84
-
0.96
-
Moderate (n = 23)
0.5–2
20
87
19
83
0.5–1.5
20
87
18
78
0.7–1.3
15
65
11
48
> 2
0
0
3
13
< 0.5
3
13
1
4
AFE
0.79
-
0.94
-
Severe (n = 11)
0.5–2
8
73
7
64
0.5–1.5
7
64
5
45
0.7–1.3
6
54
3
27
> 2
0
0
3
27
< 0.5
2
18
1
9
AFE
0.77
-
1.28
-
n = 27 drugs. -: no data. #: number of drugs. AFE: average fold error; AUC: area under the curve; mPBPK: minimal physiologically based pharmacokinetic; PBPK: physiologically based pharmacokinetic
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