Comparison between minimal and whole body PBPK prediction for Cmax
Range
mPBPK
Whole body PBPK
Within the range #
Within the range (%)
Within the range #
Within the range (%)
Mild (n = 9)
0.5–2
8
89
7
78
0.5–1.5
7
78
6
67
0.7–1.3
2
22
3
33
> 2
0
0
2
22
< 0.5
1
11
0
0
AFE
0.96
-
1.28
-
Moderate (n = 16)
0.5–2
10
63
12
75
0.5–1.5
9
56
9
56
0.7–1.3
8
50
5
31
> 2
4
25
4
25
< 0.5
2
13
0
0
AFE
1.04
-
1.22
-
Severe (n = 8)
0.5–2
3
38
4
50
0.5–1.5
1
13
3
38
0.7–1.3
1
13
2
25
> 2
5
63
4
50
< 0.5
1
13
0
0
AFE
1.66
-
1.71
-
n = 27 drugs. -: no data. #: number of drugs. AFE: average fold error; Cmax: maximum plasma concentration; mPBPK: minimal physiologically based pharmacokinetic; PBPK: physiologically based pharmacokinetic
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