Table Info

Table 2.

Kinetic parameters and results for DexaP desorption models from MSN

Model	Parameter	4°C	25°C	37°C
Zero order	k₀ (mg h^–1)	0.45 ± 0.05	0.63 ± 0.06	0.85 ± 0.08
First order	k₁ (h^–1)	0.22 ± 0.02	0.30 ± 0.03	0.41 ± 0.04
Higuchi	k_H (mg h^–1/2)	2.45 ± 0.20	3.12 ± 0.25	4.01 ± 0.30
Korsmeyer-Peppas	n	0.46 ± 0.02	0.54 ± 0.03	0.68 ± 0.04

DexaP: dexamethasone phosphate; MSN: mesoporous silica nanoparticle; k₀: zero-order related constant; k₁: first-order release constant; k_H: Higuchi constant; n: diffusional exponent

Declarations

Acknowledgments

The authors express their sincere gratitude to Dr. Gisela S. Alvarez for generously providing the 3T3 mouse fibroblast cells, to Dr. Guillermo J. Copello for his invaluable assistance with the interpretation of isotherms and kinetic data, and to Dr. Andrea M. Mebert and Dr. Rodrigo N. Nuñez for their thoughtful revisions and contributions to the final version of the manuscript.

Author contributions

JMG: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing—original draft, Writing—review & editing. MVO: Formal analysis, Investigation, Methodology, Software, Writing—original draft. AI, DHF, and CMMQ: Investigation, Writing—original draft, Writing—review & editing. MFD: Resources. HP: Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation. MVT: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing—original draft, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher.

Funding

CMMQ is grateful for her doctoral fellowship granted by Universidad de Buenos Aires [RESCD-2024-639-E-UBA-DCT]. This study received grants from the Universidad de Buenos Aires [UBACYT 20020220400378BA, UBACYT 20020190200009BA] and from Agencia Nacional de Investigaciones Científicas y Técnicas [PICT 2018-4154] (to MVT). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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