Table Info

Table 4.

Use of dupilumab as adjuvant therapy in AIT

Reference	Study type	Allergen	Patients	Main results/aims
Corren et al. [60], 2021	Phase 2, RCT, MC, DBPC	Grass	103	Dupilumab may enhance the tolerability of SCIT, but it does not appear to reduce nasal symptoms after challenge when compared to SCIT alone.
NCT03682770 [63]	Phase 2, RCT, MC, DBPC	Peanuts	149	Number of patients able to complete an exit food challenge with 2,044 mg of cumulative peanut protein.
NCT03679676 [64]	Phase 2, RCT, SC, DBPC	Multiallergen OIT	110	Number of patients who successfully passed a food challenge for peanut and two other FAs.
NCT04148352 [65]	Phase 2, RCT, MC, DBPC	Milk	40	Number of patients who received dupilumab plus milk protein OIT vs. placebo plus milk protein OIT, and were able to tolerate a minimum of 2,040 mg (cumulative) of cow’s milk protein during food challenge at week 18.

Declarations

Author contributions

PC, FS, and MFD equally contributed to: Conceptualization, Writing—original draft, Investigation. DDB and GP: Writing—original draft, Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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