Exploration of Asthma & Allergy

Table 1. Percentage of children with severe asthma sensitized to inhalants, foods, and other allergen sources according to ISAC^® results. The most relevant results are shown comparing children enrolled in Sweden

Allergenic source	STO (n = 47)	VAL (n = 29)	P
Component	STO (n = 47)	VAL (n = 29)	P
House dust mites	17	89.7	< 0.001
rDer p 1	8.5	79.3
rDer p 2	8.5	69.0
nDer p 10	6.4	41.4
rDer f 1	10.6	79.3
rDer f 2	8.5	69.0
Cladosporium	4.3	20.7	0.048
rCla h 8	4.3	20.7	0.048
Cats	72.3	55.2	0.003
rFel d 1	72.3	37.9
nFel d 2	2.1	20.7
rFel d 4	29.8	20.7
Grass pollen	63.8	41.4	0.056
rPhl p 1	40.4	17.2
rPhl p 2	10.6	6.9
nPhl p 4	38.3	34.5
rPhl p 5	29.8	6.9
rPhl p 6	17.0	10.3
rPhl p 7	0	6.9
rPhl p 11	8.5	6.9
rPhl p 12	8.5	3.5
nCyn d 1	29.8	24.1
Hazel pollen	46.8	3.5	< 0.001
rCor a 1.0101	36.2	0
rCor a 1.0401	44.7	3.5
Cockroaches	8.5	41.4	0.002
rBla g 1	2.1	0
rBla g 2	2.1	10.3
rBla g 5	2.1	3.5
nBla g 7	4.3	41.4
Alternaria	19.1	44.8	0.016
rAlt a 1	14.9	37.9
rAlt a 6	8.5	31.0
Dogs	29.8	48.3	0.105
rCan f 1	25.5	48.3
rCan f 2	17.0	13.8
nCan f 3	6.4	6.9
Birch pollen	61.7	6.9	< 0.001
rBet v 1	57.5	3.5
rBet v 2	10.6	3.5
rBet v 4	0	3.5
Alnus pollen	40.4	3.5	< 0.001
rAln g 1	40.4	3.5	< 0.001
Olive tree pollen	2.1	65.5	< 0.001
nOle e 1	2.1	65.5	< 0.001
Platanus pollen	8.5	34.5	0.007
rPla a 1	0	3.5
nPla a 2	8.5	34.5
Cypress pollen	10.6	45.0	0.002
nCup a 1	10.6	45.0	0.002
Parietaria pollen	2.1	27.6	0.002
rPar j 2	2.1	27.6	0.002
Peanuts	51.1	10.3	< 0.001
nAra h 1	23.3	6.9
nAra h 2	27.7	6.9
nAra h 3	25.5	3.5
rAra h 8	23.4	0
Soy	36.2	3.5	0.013
rGly m 4	19.2	3.5
nGly m 5	10.6	3.5
nGly m 6	17.0	3.5
Apples	40.4	3.5	< 0.001
rMal d 1	40.4	3.5	< 0.001
Celery	12.8	0	0.077
rApi g 1	12.8	0	0.077
Peaches	44.7	27.6	0.14
rPru p 1	44.7	3.5
nPru p 3	6.4	27.6
Hen’s egg	12.8	31.0	0.075
nGal d 1	10.6	24.1
nGal d 2	6.4	27.6
nGal d 3	6.4	20.7
nGal d 5	0	10.3
Kiwi	21.3	37.9	0.19
nAct d 1	14.9	10.3
nAct d 2	8.5	31.0
nAct d 5	2.1	0
Fish	0	10.3	0.052
rGad c 1	0	10.3	0.052
Shrimp	4.3	41.4	< 0.001
nPen m 1	4.3	41.4	< 0.001
Anisakis	4.3	41.4	< 0.001
rAni s 1	2.1	0
rAni s 3	4.3	41.4

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nAct d 1: Actinidia deliciosa allergen 1; nAra h 1: Arachis hypogaea allergen 1; nBla g 7: Blatella germanica allergen 7; nCup a 1: Cupressus arizonica allergen 1; nCyn d 1: Cynodon dactylon allergen 1; nGal d 1: Gallus domesticus allergen 1; nGly m 5: Glycine max allergen 5 ; nOle e 1: Olea europaea allergen 1; nPen m 1: Penaeus monodon allergen 1; nPla a 2: Platanus acerifolina allergen 2; rAln g 1: Alnus glutinosa allergen 1; rAlt a 1: Alternaria alternata allergen 1; rAni s 1: Anisakis simplex allergen 1; rApi g 1: Apium graveolens allergen 1; rBet v 1: Betula verrucosa allergen 1; rCan f 1: Canis familiaris allergen 1; rCla h 8: Cladosporium herbarum allergen 8; rCor a 1.0101: Corylus avellana allergen 1.0101; rDer f 1: Dermatophagoides farinae allergen 1; rDer p 1: Dermatophagoides pteronyssinus allergen 1; rFel d 1: Felis domesticus allergen 1; rGad c 1: Gadus callarias allergen 1; rMal d 1: Malus domestica allergen 1; rPar j 2: Parietaria judaica allergen 2; rPhl p 1: Phleum pratense allergen 1; rPla a 1: Platanus acerifolia allergen 1; rPru p 1: Prunus persica allergen 1

Supplementary materials

The supplementary material for this article is available at: https://www.explorationpub.com/uploads/Article/file/100919_sup_1.pdf.

Declarations

Acknowledgments

We gratefully thank the collaboration of ThermoFisher Scientific. This work was also supported by the Freemason Child House Foundation in Stockholm, the Consul Th. C. Bergh’s Foundation, the Swedish Asthma and Allergy Association’s Research Foundation, the Centre for Allergy Research at Karolinska Institutet, the Swedish Heart‐Lung Foundation, the Swedish Research Council, Region Stockholm (ALF-project), and the Swedish Cancer and Allergy Foundation.

Author contributions

JMG: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Visualization, Writing—original draft, Writing—review & editing. JRK: Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Writing—review & editing. GH: Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing—review & editing. MvH: Formal analysis, Investigation, Methodology, Supervision, Validation, Writing—review & editing. ANG: Conceptualization, Methodology, Resources, Supervision, Writing—review & editing. MNC and SU: Data Curation, Resources, Supervision, Writing—review & editing. AM: Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Supervision, Visualization, Writing—original draft, Writing—review & editing.

Conflicts of interest

Dr. van Hage reports personal fees from Thermo Fisher Scientific outside the submitted work. Dr. Konradsen has received research support from Thermo Fisher Scientific outside the submitted work.

Ethical approval

The study was approved by the Ethics Committee from Hospital La Fe-Comité de Ética de la Investigación con medicamentos (Registry number 2020-005-1) and sheltered by the regional board of ethics at Karolinska Institutet (Registry number Dnr 2006/1324-31/1 and 2008/378) and was conducted in accordance with the Declaration of Helsinki.

Consent to participate

The informed consent to participate was waived by the Ethics Committee from Hospital La Fe-Comité de Ética de la Investigación con medicamentos since the data collected for the study was retrospective.

Consent to publication

Not applicable.

Availability of data and materials

All data generated or analysed during this study are included in this article or its Supplementary materials. Further enquiries can be directed to the corresponding author (jaume.marti.garrido@gmail.com).

Funding

This project has been granted awards from Sociedad Española de Alergología e Inmunología Clínica (SEAIC), Asociación Valenciana de Alergia e Inmunología Clínica (AVAIC) and Colegio Oficial de Médicos de Valencia (COMV). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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