Clinical characteristics of included WALDA patients dependent on the absence or presence of wheat sIgE

Clinical characteristicsWheat sIgE < 0.35 kUA/L (n = 14)Wheat sIgE > 0.35 kUA/L (n = 22)P-value
Age, median (range)49.5 years (30–79 years)51.0 years (23–81 years)ns
Sex, male/female, n (%)6/8 (57%/43%)11/11 (50%/50%)ns
Any self-reported atopic comorbidities, n (%)4 (29%)9 (41%)ns
Years to diagnosis, median (range)3 (1–20)5 (0.5–24)ns
Severity at most severe reaction*, n (%)Grade I: 5 (36%)Grade I: 4 (18%)ns
Grade II: 2 (14%)Grade II: 4 (18%)
Grade III: 7 (50%)Grade III: 13 (59%)
Grade IV: 0 (0%)Grade IV: 1 (5%)
Total IgE, median (range)154 kUA/L (32–324 kUA/L)519 kUA/L (65–2,848 kUA/L)< 0.001
SIgE to wheat, median (range)0.12 kUA/L (< 0.10–0.32 kUA/L)0.87 kUA/L (0.47–4.65 kUA/L)< 0.001
SIgE to ω5-gliadin, median (range)2.6 kUA/L (0.5–8.8 kUA/L)9.5 kUA/L (1.8–34.6 kUA/L)< 0.001
SIgE to gliadins, median (range)3.2 kUA/L (0.3–10.3 kUA/L)0.4 kUA/L (0.2–1.6 kUA/L)< 0.001
SIgE to wheat gluten, median (range)0.6 kUA/L (< 0.1–1.6 kUA/L)3.3 kUA/L (0.5–9.9 kUA/L)< 0.001
SIgE to grass pollen, median (range)0.1 kUA/L (< 0.1–12.9 kUA/L)0.8 kUA/L (< 0.1 kUA/L–> 100 kUA/L)0.03
Positive PPST with native wheat flour, n (%)10 (71%)19 (86%)ns
Positive PPST with wheat gluten, n (%)11 (79%)20 (91%)ns
Basal serum tryptase, median (range)4.3 μg/L (3.4–9.8 μg/L)4.8 μg/L (2.3–10.7 μg/L)ns
OCT reaction threshold#, n (%)1 (1, 7.1%)1 (3, 13.6%)ns
2 (0, 0%)2 (4, 18.2%)
3 (2, 14.3%)3 (2, 9.1%)
4 (5, 35.7%)4 (6, 27.3%)
5 (1, 7.1%)5 (3, 13.6%)
6 (2, 14.3%)6 (1, 4.5%)
7 (0, 0%)7 (1, 4.5%)
8 (3, 21.4%)8 (1, 4.5%)
9 (0, 0%)9 (0, 0%)
10 (0, 0%)10 (0, 0%)
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* According to Ring and Messmer scale; # see OCTs section above. -: one missing value due to external OCT with a different protocol