Asp f: Aspergillus fumigatus; Asp n: Aspergillus niger; Asp t: Aspergillus terreus; Alt a: Alternaria alternata; Clac h: Cladosporium herbarum; Clac c: Cladosporium cucumerinum; Trit: Trichophyton; CNS: central nervous system; spp.: species
Note. Adapted from “Environment and host-genetic determinants in early development of allergic asthma: contribution of fungi,” by Hadebe S, Brombacher F. Front Immunol. 2019;10:2696 (https://doi.org/10.3389/fimmu.2019.02696). CC-BY.
The authors declare that they have no conflicts of interest.
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Availability of data and materials
All data related to the species of Aspergillus, and their cultures are from the Department of Biotechnology, Shobhit Institute of Engineering & Technology, Deemed-to-be University, Meerut, and the Research and Development Cell of Swami Vivekanand Subharti University, Meerut (India) and are available upon request from the corresponding author (amarprakashgarg@yahoo.com).
Chiu CJ, Huang MT. Asthma in the precision medicine era: biologics and probiotics.Int J Mol Sci. 2021;22:4528. [DOI] [PubMed] [PMC]
Pashley CH, Wardlaw AJ. Allergic fungal airways disease (AFAD): an under-recognised asthma endotype.Mycopathologia. 2021;186:609–22. [DOI] [PubMed] [PMC]
Papi A, Vestbo J, Fabbri L, Corradi M, Prunier H, Cohuet G, et al. Extrafine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised controlled trial.Lancet. 2018;391:1076–84.Erratum in: Lancet. 2018;391:1022. [DOI] [PubMed]
Kaur R, Chupp G. Phenotypes and endotypes of adult asthma: moving toward precision medicine.J Allergy Clin Immunol. 2019;144:1–12. [DOI] [PubMed]
Shrine N, Portelli MA, John C, Soler Artigas M, Bennett N, Hall R, et al. Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.Lancet Respir Med. 2019;7:20–34. [DOI] [PubMed] [PMC]
Reddel HK, Bacharier LB, Bateman ED, Brightling CE, Brusselle GG, Buhl R, et al. Global Initiative for Asthma Strategy 2021: executive summary and rationale for key changes.Am J Respir Crit Care Med. 2022;205:17–35. [DOI] [PubMed] [PMC]
Denning DW, O’Driscoll BR, Hogaboam CM, Bowyer P, Niven RM. The link between fungi and severe asthma: a summary of the evidence.Eur Respir J. 2006;27:615–26. [DOI] [PubMed]
Mistry H, Ajsivinac Soberanis HM, Kyyaly MA, Azim A, Barber C, Knight D, et al. The clinical implications of Aspergillus fumigatus sensitization in difficult-to-treat asthma patients.J Allergy Clin Immunol Pract. 2021;9:4254–67.E10. [DOI] [PubMed]
Rimek D, Garg AP, Kappe R, Sonntag HG. Fungal PCR-assay for the detection of invasive aspergillosis.Mycoses. 1998;41:65–8. German. [DOI] [PubMed]
Rimek D, Garg AP, Haas WH, Kappe R. Identification of contaminating fungal DNA sequences in zymolyase.J Clin Microbiol. 1999;37:830–1. [DOI] [PubMed] [PMC]
Tosca MA, Schiavetti I, Duse M, Marseglia GL, Ciprandi G; Asthma Committee of the SIAIP. A survey on the management of children with asthma in primary care setting in Italy.Pediatr Allergy Immunol Pulmonol. 2021;34:39–42. [DOI] [PubMed] [PMC]
Athari SS, Athari SM. The importance of eosinophil, platelet and dendritic cell in asthma.Asian Pac J Trop Dis. 2014;4:S41–7. [DOI]
Athari SM, Nasab ME, Athari SS. Study effect of Ocimum basilicum seeds on mucus production and cytokine gene expression in allergic asthma mice model.Rev Franc d’Allergolo. 2018;58:489–93. [DOI]
Wu Z, Mehrabi Nasab E, Arora P, Athari SS. Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4/NF-kB signaling pathway.J Transl Med. 2022;20:130. [DOI] [PubMed] [PMC]
Mosconi I, Geuking MB, Zaiss MM, Massacand JC, Aschwanden C, Kwong Chung CK, et al. Intestinal bacteria induce TSLP to promote mutualistic T-cell responses.Mucosal Immunol. 2013;6:1157–67. [DOI] [PubMed]
Lee YY, Leow AH, Chai PF, Raja Ali RA, Lee WS, Goh KL. Use of probiotics in clinical practice with special reference to diarrheal diseases: a position statement of the Malaysian Society of Gastroenterology and Hepatology.JGH Open. 2020;5:11–9. [DOI] [PubMed] [PMC]
Johnson D, Letchumanan V, Thum CC, Thurairajasingam S, Lee LH. A microbial-based approach to mental health: the potential of probiotics in the treatment of depression.Nutrients. 2023;15:1382. [DOI] [PubMed] [PMC]
Bush A. Kids, difficult asthma and fungus.J Fungi (Basel). 2020;6:55. [DOI] [PubMed] [PMC]
Targonski PV, Persky VW, Ramekrishnan V. Effect of environmental molds on risk of death from asthma during the pollen season.J Allergy Clin Immunol. 1995;95:955–61. [DOI] [PubMed]
O’Hollaren MT, Yunginger JW, Offord KP, Somers MJ, O’Connell EJ, Ballard DJ, et al. Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma.N Engl J Med. 1991;324:359–63. [DOI] [PubMed]
Downs SH, Mitakakis TZ, Marks GB, Car NG, Belousova EG, Leüppi JD, et al. Clinical importance of Alternaria exposure in children.Am J Respir Crit Care Med. 2001;164:455–9. [DOI] [PubMed]
Denning DW, Pashley C, Hartl D, Wardlaw A, Godet C, Del Giacco S, et al. Fungal allergy in asthma–state of the art and research needs.Clin Transl Allergy. 2014;4:14. [DOI] [PubMed] [PMC]
Medrek SK, Kao CC, Yang DH, Hanania NA, Parulekar AD. Fungal sensitization is associated with increased risk of life-threatening asthma.J Allergy Clin Immunol Pract. 2017;5:1025–31.E2. [DOI] [PubMed]
McLeish AC, Farris SG, Johnson AL, Bernstein JA, Zvolensky MJ. An examination of the indirect effect of anxiety sensitivity in terms of asthma and smoking cessation processes.Addict Behav. 2015;50:188–91. [DOI] [PubMed]
Menzies D, Holmes L, McCumesky G, Prys-Picard C, Niven R. Aspergillus sensitization is associated with airflow limitation and bronchiectasis in severe asthma.Allergy. 2011;66:679–85. [DOI] [PubMed]
Vicencio AG, Santiago MT, Tsirilakis K, Stone A, Worgall S, Foley EA, et al. Fungal sensitization in childhood persistent asthma is associated with disease severity.Pediatr Pulmonol. 2014;49:8–14. [DOI] [PubMed]
Rick EM, Woolnough K, Pashley CH, Wardlaw AJ. Allergic fungal airway disease.J Investig Allergol Clin Immunol. 2016;26:344–54. [DOI] [PubMed]
Denning DW, Pleuvry A, Cole DC. Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults.Med Mycol. 2013;51:361–70. [DOI] [PubMed]
Armstead J, Morris J, Denning DW. Multi-country estimate of different manifestations of aspergillosis in cystic fibrosis.PLoS One. 2014;9:e98502. [DOI] [PubMed] [PMC]
Knutsen AP, Slavin RG. Allergic bronchopulmonary aspergillosis in asthma and cystic fibrosis.Clin Dev Immunol. 2011;2011:843763. [DOI] [PubMed] [PMC]
Kwon-Chung KJ, Sugui JA. Aspergillus fumigatus—What makes the species a ubiquitous human fungal pathogen?PLoS Pathog. 2013;9:e1003743. [DOI] [PubMed] [PMC]
Loss GJ, Depner M, Hose AJ, Genuneit J, Karvonen AM, Hyvärinen A, et al.; PASTURE (Protection against Allergy Study in Rural Environments) Study Group. The early development of wheeze. environmental determinants and genetic susceptibility at 17q21.Am J Respir Crit Care Med. 2015;193:889–97.Erratum in: Am J Respir Crit Care Med. 2019;200:946. [DOI] [PubMed]
O’Driscoll BR, Hopkinson LC, Denning DW. Mold sensitization is common amongst patients with severe asthma requiring multiple hospital admissions.BMC Pulm Med. 2005;5:4. [DOI] [PubMed] [PMC]
Fraczek MG, Chishimba L, Niven RM, Bromley M, Simpson A, Smyth L, et al. Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease.J Allergy Clin Immunol. 2018;142:407–14. [DOI] [PubMed]
Porter PC, Ongeri V, Luong A, Kheradmand F, Corry DB. Seeking common pathophysiology in asthma, atopy and sinusitis.Trends Immunol. 2011;32:43–9. [DOI] [PubMed] [PMC]
Porter P, Susarla SC, Polikepahad S, Qian Y, Hampton J, Kiss A, et al. Link between allergic asthma and airway mucosal infection suggested by proteinase-secreting household fungi.Mucosal Immunol. 2009;2:504–17. [DOI] [PubMed] [PMC]
Williams PB, Barnes CS, Portnoy JM; Environmental Allergens Workgroup. Innate and adaptive immune response to fungal products and allergens.J Allergy Clin Immunol Pract. 2016;4:386–95. [DOI] [PubMed]
Black PN, Udy AA, Brodie SM. Sensitivity to fungal allergens is a risk factor for life-threatening asthma.Allergy. 2000;55:501–4. [DOI] [PubMed]
Castanhinha S, Sherburn R, Walker S, Gupta A, Bossley CJ, Buckley J, et al. Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33.J Allergy Clin Immunol. 2015;136:312–22.E7. [DOI] [PubMed] [PMC]
Grewling Ł, Nowak M, Szymańska A, Kostecki Ł, Bogawski P. Temporal variability in the allergenicity of airborne Alternaria spores.Med Mycol. 2018;57:403–11. [DOI] [PubMed] [PMC]
Chiba S, Okada S, Suzuki Y, Watanuki Z, Mitsuishi Y, Igusa R, et al. Cladosporium species-related hypersensitivity pneumonitis in household environments.Intern Med. 2009;48:363–7. [DOI] [PubMed]
Grava S, Lopes FA, Cavallazzi RS, Grassi MF, Svidzinski TI. A rare case of hemorrhagic pneumonia due to Cladosporium cladosporioides.J Bras Pneumol. 2016;42:392–4. [DOI] [PubMed] [PMC]
Chou H, Tam MF, Chiang CH, Chou CT, Tai HY, Shen HD. Transaldolases are novel and immunoglobulin E cross-reacting fungal allergens.Clin Exp Allergy. 2011;41:739–49. [DOI] [PubMed]
van Woerden HC, Gregory C, Brown R, Marchesi JR, Hoogendoorn B, Matthews IP. Differences in fungi present in induced sputum samples from asthma patients and non-atopic controls: a community based case control study.BMC Infect Dis. 2013;13:69. [DOI] [PubMed] [PMC]
Prohic A, Jovovic Sadikovic T, Krupalija-Fazlic M, Kuskunovic-Vlahovljak S. Malassezia species in healthy skin and in dermatological conditions.Int J Dermatol. 2016;55:494–504. [DOI] [PubMed]
Wozniak KL, Olszewski MA, Wormley FL Jr. Molecules at the interface of Cryptococcus and the host that determine disease susceptibility.Fungal Genet Biol. 2015;78:87–92. [DOI] [PubMed]
Wiesner DL, Specht CA, Lee CK, Smith KD, Mukaremera L, Lee ST, et al. Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection.PLoS Pathog. 2015;11:e1004701. [DOI] [PubMed] [PMC]
Fritz JH, Rojas OL, Simard N, McCarthy DD, Hapfelmeier S, Rubino S, et al. Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut.Nature. 2011;481:199–203. [DOI] [PubMed] [PMC]
Sugui JA, Kwon-Chung KJ, Juvvadi PR, Latgé JP, Steinbach WJ. Aspergillus fumigatus and related species.Cold Spring Harb Perspect Med. 2014;5:a019786. [DOI] [PubMed] [PMC]
Sander I, Raulf-Heimsoth M, Siethoff C, Lohaus C, Meyer HE, Baur X. Allergy to Aspergillus-derived enzymes in the baking industry: identification of β-xylosidase from Aspergillus niger as a new allergen (Asp n 14).J Allergy Clin Immunol. 1998;102:256–64. [DOI] [PubMed]
Karmakar B, Saha B, Jana K, Gupta Bhattacharya S. Identification and biochemical characterization of Asp t 36, a new fungal allergen from Aspergillus terreus.J Biol Chem. 2020;295:17852–64.Erratum in: J Biol Chem. 2021;296:100379. [DOI] [PubMed] [PMC]
Agarwal R. Severe asthma with fungal sensitization.Curr Allergy Asthma Rep. 2011;11:403–13. [DOI] [PubMed]
Knutsen AP, Bush RK, Demain JG, Denning DW, Dixit A, Fairs A, et al. Fungi and allergic lower respiratory diseases.J Allergy Clin Immunol. 2012;129:280–91. [DOI] [PubMed]
Kustrzeba-Wójcicka I, Siwak E, Terlecki G, Wolańczyk-Mędrala A, Mędrala W. Alternaria alternata and its allergens: a comprehensive review.Clin Rev Allergy Immunol. 2014;47:354–65. [DOI] [PubMed]
Ishibashi Y, Kato H, Asahi Y, Sugita T, Nishikawa A. Identification of the major allergen of Malassezia globosa relevant for atopic dermatitis.J Dermatol Sci. 2009;55:185–92. [DOI] [PubMed]
Akar-Ghibril N, Casale T, Custovic A, Phipatanakul W. Allergic endotypes and phenotypes of asthma.J Allergy Clin Immunol Pract. 2020;8:429–40.Erratum in: J Allergy Clin Immunol Pract. 2020;8:1779. [DOI] [PubMed] [PMC]
Martens K, Pugin B, De Boeck I, Spacova I, Steelant B, Seys SF, et al. Probiotics for the airways: potential to improve epithelial and immune homeostasis.Allergy. 2018;73:1954–63. [DOI] [PubMed]
Gaillard EA, Kuehni CE, Turner S, Goutaki M, Holden KA, de Jong CC, et al. European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5–16 years.Eur Respir J. 2021;58:2004173. [DOI] [PubMed]
Mennini M, Dahdah L, Artesani MC, Fiocchi A, Martelli A. Probiotics in asthma and allergy prevention.Front Pediatr. 2017;5:165. [DOI] [PubMed] [PMC]
van Loveren H, Sanz Y, Salminen S. Health claims in Europe: probiotics and prebiotics as case examples.Annu Rev Food Sci Technol. 2012;3:247–61. [DOI] [PubMed]
Vliagoftis H, Kouranos VD, Betsi GI, Falagas ME. Probiotics for the treatment of allergic rhinitis and asthma: systematic review of randomized controlled trials.Anna Aller Asthma Immunol. 2008;101:570–9. [DOI] [PubMed]
Dargahi N, Johnson J, Donkor O, Vasiljevic T, Apostolopoulos V. Immunomodulatory effects of probiotics: Can they be used to treat allergies and autoimmune diseases?Maturitas. 2019;119:25–38. [DOI] [PubMed]
Mohammed SK, Magdy YM, El-Waseef DA, Nabih ES, Hamouda MA, El-Kharashi OA. Modulation of hippocampal TLR4/BDNF signal pathway using probiotics is a step closer towards treating cognitive impairment in NASH model.Physiol Behav. 2020;214:112762. [DOI] [PubMed]
Suadoni MT. Correspondence on ‘A. Grylls, K. Seidler, J. Neil, Link between microbiota and hypertension: focus on LPS/TLR4 pathway in endothelial dysfunction and vascular inflammation, and therapeutic implication of probiotics’.Biomed Pharmacother. 2021;138:111432. [DOI] [PubMed]
Tang J, Xu L, Zeng Y, Gong F. Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway.Int Immunopharmacol. 2021;91:107272. [DOI] [PubMed]
Tirpude NV, Sharma A, Joshi R, Kumari M, Acharya V. Vitex negundo Linn. extract alleviates inflammatory aggravation and lung injury by modulating AMPK/PI3K/Akt/p38-NF-κB and TGF-β/Smad/Bcl2/caspase/LC3 cascade and macrophages activation in murine model of OVA-LPS induced allergic asthma.J Ethnopharmacol. 2021;271:113894. [DOI] [PubMed]
Guo S, Li W, Chen F, Yang S, Huang Y, Tian Y, et al. Polysaccharide of Atractylodes macrocephala Koidz regulates LPS-mediated mouse hepatitis through the TLR4-MyD88-NFκB signaling pathway.Int Immunopharmacol. 2021;98:107692. [DOI] [PubMed]
Bian M, Wang J, Wang Y, Nie A, Zhu C, Sun Z, et al. Chicory ameliorates hyperuricemia via modulating gut microbiota and alleviating LPS/TLR4 axis in quail.Biomed Pharmacother. 2020;131:110719. [DOI] [PubMed]
Milani C, Duranti S, Bottacini F, Casey E, Turroni F, Mahony J, et al. The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota.Microbiol Mol Biol Rev. 2017;81:e00036-17. [DOI] [PubMed] [PMC]
Stinson LF, Boyce MC, Payne MS, Keelan JA. The not-so-sterile womb: evidence that the human fetus is exposed to bacteria prior to birth.Front Microbiol. 2019;10:1124. [DOI] [PubMed] [PMC]
Mackie RI, Sghir A, Gaskins HR. Developmental microbial ecology of the neonatal gastrointestinal tract.Am J Clin Nutr. 1999;69:1035S–45S. [DOI] [PubMed]
Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic.Nat Rev Gastroenterol Hepatol. 2014;11:506–14. [DOI] [PubMed]
Furrie E. Probiotics and allergy.Proc Nutr Soc. 2005;64:465–9. [DOI] [PubMed]
Zuccotti G, Meneghin F, Aceti A, Barone G, Callegari ML, Di Mauro A, et al. Probiotics for prevention of atopic diseases in infants: systematic review and meta-analysis.Allergy. 2015;70:1356–71. [DOI] [PubMed]
Sestito S, D’Auria E, Baldassarre ME, Salvatore S, Tallarico V, Stefanelli E, et al. The role of prebiotics and probiotics in prevention of allergic diseases in infants.Front Pediatr. 2020;8:583946. [DOI] [PubMed] [PMC]
Tan-Lim CSC, Esteban-Ipac NAR, Recto MST, Castor MAR, Casis-Hao RJ, Nano ALM. Comparative effectiveness of probiotic strains on the prevention of pediatric atopic dermatitis: a systematic review and network meta-analysis.Pediatr Allergy Immunol. 2021;32:1255–70. [DOI] [PubMed]
Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system.Science. 2012;336:1268–73. [DOI] [PubMed] [PMC]
Rudensky AY, Chervonsky AV. A narrow circle of mutual friends.Immunity. 2011;34:697–9. [DOI] [PubMed]
Furrie E, Turner MW, Strobel S. Failure of SCID mice to generate an oral tolerogen after a feed of ovalbumin: a role for a functioning gut-associated lymphoid system.Immunology. 1994;83:562–7. [PubMed] [PMC]
Wambre E, Jeong D. Oral tolerance development and maintenance.Immunol Allergy Clin North Am. 2018;38:27–37. [DOI] [PubMed] [PMC]
Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system.Cell. 2005;122:107–18. [DOI] [PubMed]
McLoughlin RM, Mills KH. Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma.J Allergy Clin Immunol. 2011;127:1097–107.Erratum in: J Allergy Clin Immunol. 2011;128:253. [DOI] [PubMed]
Maldonado Galdeano C, Cazorla SI, Lemme Dumit JM, Vélez E, Perdigón G. Beneficial effects of probiotic consumption on the immune system.Ann Nutr Metab. 2019;74:115–24. [DOI] [PubMed]
Ciprandi G, Tosca MA. Probiotics in children with asthma.Children (Basel). 2022;9:978. [DOI] [PubMed] [PMC]
Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria.Cell. 2009;139:485–98. [DOI] [PubMed] [PMC]
Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, et al. Induction of colonic regulatory T cells by indigenous Clostridium species.Science. 2011;331:337–41. [DOI] [PubMed] [PMC]
Noval Rivas M, Burton OT, Wise P, Zhang YQ, Hobson SA, Garcia Lloret M, et al. A microbiota signature associated with experimental food allergy pro-motes allergic sensitization and anaphylaxis.J Allergy Clin Immunol. 2013;131:201–12. [DOI] [PubMed] [PMC]
Vernocchi P, Del Chierico F, Fiocchi AG, El Hachem M, Dallapiccola B, Rossi P, et al. Understanding probiotics’ role in allergic children: the clue of gut microbiota profiling.Curr Opin Allergy Clin Immunol. 2015;15:495–503. [DOI] [PubMed]
Thompson-Chagoyan OC, Vieites JM, Maldonado J, Edwards C, Gil A. Changes in faecal microbiota of infants with cow’s milk protein allergy – a Spanish prospective case–control 6-month follow-up study.Pediatr Allergy Immunol. 2010;21:e394–400. [DOI] [PubMed]
Kabat AM, Srinivasan N, Maloy KJ. Modulation of immune development and function by intestinal microbiota.Trends Immunol. 2014;35:507–17. [DOI] [PubMed] [PMC]
Wang S, Charbonnier LM, Noval Rivas M, Georgiev P, Li N, Gerber G, et al. MyD88 adaptor-dependent microbial sensing by regulatory T cells promotes mucosal tolerance and enforces commensalism.Immunity. 2015;43:289–303. [DOI] [PubMed] [PMC]
Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota.Science. 2011;332:974–7. [DOI] [PubMed] [PMC]
Huang J, Zhang J, Wang X, Jin Z, Zhang P, Su H, et al. Effect of probiotics on respiratory tract allergic disease and gut microbiota.Front Nutr. 2022;9:821900. [DOI] [PubMed] [PMC]
Al Nabhani Z, Eberl G. Imprinting of the immune system by the microbiota early in life.Mucosal Immunol. 2020;13:183–9. [DOI] [PubMed]
Rautava S, Isolauri E. The development of gut immune responses and gut microbiota: effects of probiotics in prevention and treatment of allergic disease.Curr Issues Intest Microbiol. 2002;3:15–22. [PubMed]
Cristofori F, Dargenio VN, Dargenio C, Miniello VL, Barone M, Francavilla R. Anti-inflammatory and immunomodulatory effects of probiotics in gut inflammation: a door to the body.Front Immunol. 2021;12:578386. [DOI] [PubMed] [PMC]
Wang HT, Anvari S, Anagnostou K. The role of probiotics in preventing allergic disease.Children (Basel). 2019;6:24. [DOI] [PubMed] [PMC]
Balta I, Butucel E, Mohylyuk V, Criste A, Dezmirean DS, Stef L, et al. Novel insights into the role of probiotics in respiratory infections, allergies, cancer, and neurological abnormalities.Diseases. 2021;9:60. [DOI] [PubMed] [PMC]
Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.Nature. 2013;504:446–50.Erratum in: Nature. 2014;506:254. [DOI] [PubMed]
Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.Nature. 2013;504:451–5. [DOI] [PubMed] [PMC]
Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis.Nat Med. 2014;20:159–66. [DOI] [PubMed]
Nieto A, Wahn U, Bufe A, Eigenmann P, Halken S, Hedlin G, et al. Allergy and asthma prevention 2014.Pediatr Allergy Immunol. 2014;25:516–33. [DOI] [PubMed]
Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction.J Immunol. 1997;159:1739–45. [DOI] [PubMed]
Geuking MB, Cahenzli J, Lawson MA, Ng DC, Slack E, Hapfelmeier S, et al. Intestinal bacterial colonization induces mutualistic regulatory T cell responses.Immunity. 2011;34:794–806. [DOI] [PubMed]
Otani IM, Anilkumar AA, Newbury RO, Bhagat M, Beppu LY, Dohil R, et al. Anti–IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis.J Allergy Clin Immunol. 2013;131:1576–82.E2. [DOI] [PubMed] [PMC]
Saenz SA, Taylor BC, Artis D. Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites.Immunol Rev. 2008;226:172–90. [DOI] [PubMed] [PMC]
Okada S, Kita H, George TJ, Gleich GJ, Leiferman KM. Migration of eosin-ophils through basement membrane componentsin vitro: role of matrix metalloproteinase-9.Am J Respir Cell Mol Biol. 1997;17:519–28. [DOI] [PubMed]
Wu CT, Chen PJ, Lee YT, Ko JL, Lue KH. Effects of immunomodulatory supplementation with Lactobacillus rhamnosus on airway inflammation in a mouse asthma model.J Microbiol Immunol Infect. 2016;49:625–35. [DOI] [PubMed]
Elazab N, Mendy A, Gasana J, Vieira ER, Quizon A, Forno E. Probiotic administration in early life, atopy, and asthma: a meta-analysis of clinical trials.Pediatrics. 2013;132:e666–76. [DOI] [PubMed]
Kalliomäki M, Salminen S, Poussa T, Arvilommi H, Isolauri E. Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial.Lancet. 2003;361:1869–71. [DOI] [PubMed]
Kuitunen M, Kukkonen K, Juntunen-Backman K, Korpela R, Poussa T, Tuure T, et al. Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort.J Allergy Clin Immunol. 2009;123:335–41. [DOI] [PubMed]
Abrahamsson TR, Jakobsson T, Björkstén B, Oldaeus G, Jenmalm MC. No effect of probiotics on respiratory allergies: a seven-year follow-up of a randomized controlled trial in infancy.Pediatr Allergy Immunol. 2013;24:556–61. [DOI] [PubMed]
Wickens K, Stanley TV, Mitchell EA, Barthow C, Fitzharris P, Purdie G, et al. Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: Does it also reduce atopic sensitization?Clin Exp Allergy. 2013;43:1048–57. [DOI] [PubMed]
West CE, Hammarström ML, Hernell O. Probiotics in primary prevention of allergic disease – follow-up at 8–9 years of age.Allergy. 2013;68:1015–20. [DOI] [PubMed]
Gorissen DM, Rutten NB, Oostermeijer CM, Niers LE, Hoekstra MO, Rijkers GT, et al. Preventive effects of selected probiotic strains on the development of asthma and allergic rhinitis in childhood. The Panda study.Clin Exp Allergy. 2014;44:1431–3. [DOI] [PubMed]
Forsberg A, West CE, Prescott SL, Jenmalm MC. Pre- and probiotics for allergy prevention: time to revisit recommendations?Clin Exp Allergy. 2016;46:1506–21. [DOI] [PubMed]
West CE, Jenmalm MC, Kozyrskyj AL, Prescott SL. Probiotics for treatment and primary prevention of allergic diseases and asthma: looking back and moving forward.Expert Rev Clin Immunol. 2016;12:625–39. [DOI] [PubMed]
Cuello-Garcia CA, Brożek JL, Fiocchi A, Pawankar R, Yepes-Nuñez JJ, Terracciano L, et al. Probiotics for the prevention of allergy: a systematic review and meta-analysis of randomized controlled trials.J Allergy Clin Immunol. 2015;136:952–61. [DOI] [PubMed]
Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, et al. Human gut microbiome viewed across age and geography.Nature. 2012;486:222–7. [DOI] [PubMed] [PMC]
Pellaton C, Nutten S, Thierry AC, Boudousquié C, Barbier N, Blanchard C, et al. Intragastric and intranasal administration of Lactobacillus paracasei NCC2461 modulates allergic airway inflammation in mice.Int J Inflamm. 2012;2012:686739. [DOI] [PubMed] [PMC]
Jan RL, Yeh KC, Hsieh MH, Lin YL, Kao HF, Li PH, et al. Lactobacillus gasseri suppresses Th17 pro-inflammatory response and attenuates allergen-induced airway inflammation in a mouse model of allergic asthma.Br J Nutr. 2012;108:130–9. [DOI] [PubMed]
Schabussova I, Hufnagl K, Tang ML, Hoflehner E, Wagner A, Loupal G, et al. Perinatal maternal administration of Lactobacillus paracasei NCC 2461 prevents allergic inflammation in a mouse model of birch pollen allergy.PLoS One. 2012;7:e40271. [DOI] [PubMed] [PMC]
Lee J, Yang W, Hostetler A, Schultz N, Suckow MA, Stewart KL, et al. Characterization of the anti-inflammatory Lactobacillus reuteri BM36301 and its probiotic benefits on aged mice.BMC Microbiol. 2016;16:69. [DOI] [PubMed] [PMC]
Mårtensson A, Abolhalaj M, Lindstedt M, Mårtensson A, Olofsson TC, Vásquez A, et al. Clinical efficacy of a topical lactic acid bacterial microbiome in chronic rhinosinusitis: a randomized controlled trial.Laryngoscope Investig Otolaryngol. 2017;2:410–6. [DOI] [PubMed] [PMC]
Spacova I, Petrova MI, Fremau A, Pollaris L, Vanoirbeek J, Ceuppens JL, et al. Intranasal administration of probiotic Lactobacillus rhamnosus GG prevents birch pollen-induced allergic asthma in a murine model.Allergy. 2019;74:100–10. [DOI] [PubMed]
Lokshina EE, Kravchenko OV, Zaytseva OV. Pidotimod in treatment of children with acute respiratory infection with the concomitant recurrent obstructive syndrome.Curr Pediatr. 2011;10:34–41.
Zajac AE, Adams AS, Turner JH. A systematic review and meta-analysis of probiotics for the treatment of allergic rhinitis.Int Forum Allergy Rhinol. 2015;5:524–32. [DOI] [PubMed] [PMC]
Güvenç IA, Muluk NB, Mutlu FŞ, Eşki E, Altıntoprak N, Oktemer T, et al. Do probiotics have a role in the treatment of allergic rhinitis? A comprehensive systematic review and meta-analysis.Am J Rhinol Allergy. 2016;30:157–75. [DOI] [PubMed]
Peng Y, Li A, Yu L, Qin G. The role of probiotics in prevention and treatment for patients with allergic rhinitis: a systematic review.Am J Rhinol Allergy. 2015;29:292–8. [DOI] [PubMed]
Martens K, Pugin B, De Boeck I, Spacova I, Steelant B, Seys SF, et al. Probiotics for the airways: potential to improve epithelial and immune homeostasis.Allergy. 2018;73:1954–63. [DOI] [PubMed]
Hartsock A, Nelson WJ. Adherens and tight junctions: structure, function and connections to the actin cytoskeleton.Biochem Biophys Acta. 2008;1778:660–9. [DOI] [PubMed] [PMC]
Abreu NA, Nagalingam NA, Song Y, Roediger FC, Pletcher SD, Goldberg AN, et al. Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis.Sci Transl Med. 2012;4:151ra24. [DOI] [PubMed] [PMC]
Kitz R, Martens U, Zieseniß E, Enck P, Rose MA. Probiotic E.faecalis — adjuvant therapy in children with recurrent rhinosinusitis.Cent Eur J Med. 2012;7:362–5. [DOI]
Marchisio P, Santagati M, Scillato M, Baggi E, Fattizzo M, Rosazza C, et al. Streptococcus salivarius 24SMB administered by nasal spray for the prevention of acute otitis media in otitis-prone children.Eur J Clin Microbiol Infect Dis. 2015;34:2377–83. [DOI] [PubMed]
Chen YS, Jan RL, Lin YL, Chen HH, Wang JY. Randomized placebocontrolled trial of lactobacillus on asthmatic children with allergic rhinitis.Pediatr Pulmonol. 2010;45:1111–20. [DOI] [PubMed]
Gutkowski P, Madaliński K, Grek M, Dmeńska H, Syczewska M, Michałkiewicz J. Clinical immunology effect of orally administered probiotic strain Lactobacillus and Bifidobacterium in children with atopic asthma.Cent Eur J Immunol. 2010;35:233–8.
van de Pol MA, Lutter R, Smids BS, Weersink EJ, van der Zee JS. Synbiotics reduce allergen-induced T-helper 2 response and improve peak expiratory flow in allergic asthmatics.Allergy. 2011;66:39–47. [DOI] [PubMed]
Rose MA, Stieglitz F, Köksal A, Schubert R, Schulze J, Zielen S. Efficacy of probiotic Lactobacillus GG on allergic sensitization and asthma in infants at risk.Clin Exp Allergy. 2010;40:1398–405. [DOI] [PubMed]
Muraro A, Halken S, Arshad SH, Beyer K, Dubois AE, Du Toit G, et al.; EAACI Food Allergy and Anaphylaxis Guidelines Group. EAACI Food Allergy and Anaphylaxis Guidelines. Primary prevention of food allergy.Allergy. 2014;69:590–601. [DOI] [PubMed]
Braegger C, Chmielewska A, Decsi T, Kolacek S, Mihatsch W, Moreno L, et al.; ESPGHAN Committee on Nutrition. Supplementation of infant formula with probiotics and/or prebiotics: a systematic review and comment by the ESPGHAN Committee on Nutrition.J Pediatr Gastroenterol Nutr. 2011;52:238–50. [DOI] [PubMed]
Fiocchi A, Pawankar R, Cuello-Garcia C, Ahn K, Al-Hammadi S, Agarwal A, et al. World Allergy Organization-McMaster University Guidelines for allergic disease prevention (GLAD-P): probiotics.World Allergy Organ J. 2015;8:4. [DOI] [PubMed] [PMC]
Kaczynska A, Kłosińska M, Ostojska M, Nowak E, Stanicki P. The role of immunomodulatory preparations in asthma treatment.J Educ Health Sport. 2021;11:300–6. [DOI]
Zuccotti G, Meneghin F, Aceti A, Barone G, Callegari ML, Di Mauro A, et al.; Italian Society of Neonatology. Probiotics for prevention of atopic diseases in infants: systematic review and meta-analysis.Allergy. 2015;70:1356–71. [DOI] [PubMed]
Lin J, Zhang Y, He C, Dai J. Probiotics supplementation in children with asthma: a systematic review and meta-analysis.J Paediatr Child Health. 2018;54:953–61. [DOI] [PubMed]
Wei X, Jiang P, Liu J, Sun R, Zhu L. Association between probiotic supplementation and asthma incidence in infants: a meta-analysis of randomized controlled trials.J Asthma. 2020;57:167–78. [DOI] [PubMed]
Tang ML, Lahtinen SJ, Boyle RJ. Probiotics and prebiotics: clinical effects in allergic disease.Curr Opin Pediatr. 2010;22:626–34. [DOI] [PubMed]
Banche G, Allizond V, Mandras N, Garzaro M, Cavallo GP, Baldi C, et al. Improvement of clinical response in allergic rhinitis patients treated with an oral immunostimulating bacterial lysate: in vivo immunological effects.Int J Immunopathol Pharmacol. 2007;20:129–38. [DOI] [PubMed]
Esposito S, Soto-Martinez ME, Feleszko W, Jones MH, Shen KL, Schaad UB. Nonspecific immunomodulators for recurrent respiratory tract infections, wheezing and asthma in children: a systematic review of mechanistic and clinical evidence.Curr Opin Allergy Clin Immunol. 2018;18:198–209. [DOI] [PubMed] [PMC]
Yin J, Xu B, Zeng X, Shen K. Broncho-Vaxom in pediatric recurrent respiratory tract infections: a systematic review and meta-analysis.Int Immunopharmacol. 2018;54:198–209. [DOI] [PubMed]
de Boer GM, Żółkiewicz J, Strzelec KP, Ruszczyński M, Hendriks RW, Braunstahl GJ, et al. Bacterial lysate therapy for the prevention of wheezing episodes and asthma exacerbations: a systematic review and meta-analysis.Eur Respir Rev. 2020;29:190175. [DOI] [PubMed] [PMC]
Carta S, Silvestri M, Rossi GA. Modulation of airway epithelial cell functions by pidotimod: NF-kB cytoplasmatic expression and its nuclear translocation are associated with an increased TLR-2 expression.Ital J Pediatr. 2013;39:29. [DOI] [PubMed] [PMC]
Namazova-Baranova LS, Alekseeva AA, Kharit SM, Kozhevnikova TN, Taranushenko TE, Tuzankina IA, et al. Efficacy and safety of pidotimod in the prevention of recurrent respiratory infections in children: a multicentre study.Int J Immunopathol Pharmacol. 2014;27:413–9. [DOI] [PubMed]
