Summary of selected supporting literature
| Relevant findings | Author [Ref] | Date of publication | Study design |
|---|---|---|---|
| Mitochondrial dysfunction is increased in the asthmatic airway epithelium | Zhao et al. [27] | 2023 | Gene analysis of airway epithelial brushings from healthy and asthmatic patients |
| Increased oxidative stress and damage in asthmatic patients | Gazdík et al. [20] | 2002 | Levels of co-enzyme Q10 measured in asthmatic and control patients |
| Bronchial epithelial cells display increased glycolysis in asthmatics | Winnica et al. [6] | 2019 | Airway epithelial cells isolated from healthy and asthmatic patients |
| Aerobic glycolysis is up-regulated in airway epithelial cells in asthma | Yu et al. [7] | 2022 | Ovalbumin-sensitized mouse model and in vitro investigation of human bronchial epithelial cell lines |
| Asthma increases epithelial cell apoptosis | Iwata et al. [54] | 2003 | Ovalbumin-sensitized mouse model |
| Trautmann et al. [55] | 2005 | Evaluated epithelial layer of bronchial biopsies from asthma patients | |
| Truong-Tran et al. [56] | 2002 | Ovalbumin-sensitized mouse model | |
| Dorscheid et al. [57] | 2003 | Ovalbumin-sensitized mouse model | |
| Proliferation is increased in asthma airway epithelial cells after allergen challenge | Hastie et al. [61] | 2002 | In vitro study of human epithelial cells from asthmatic and non-asthmatics |
| Epithelial cell proliferation contributes to airway remodeling in severe asthma | Cohen et al. [62] | 2007 | Epithelial cells examined from bronchial biopsy from asthmatic and healthy patients |
| Reduced ETC complex I and III activity in airway inflammation in asthmatics | Niu et al. [47] | 2020 | Lung tissue and monocytes from ovalbumin-sensitized mouse model evaluated |
| Increased demand for NAD+ drives up-regulation of aerobic glycolysis | Luengo et al. [45] | 2021 | In vitro investigation of malignant and non-transformed cell populations (airway cell lines not involved in the study) |
| Aerobic glycolysis rate limiting factor for proliferation in airway epithelial cells | Park et al. [44] | 2024 | In vitro study of bronchial epithelial cells |
| Inflammation-induced cell proliferation potentiates DNA damage-induced mutations | Kiraly et al. [69] | 2015 | In vivo mouse model examining overall mutation rate |
| Asthma significantly associated with increased lung cancer risk | Qu et al. [16] | 2017 | Meta-analysis |
ETC: electron transport chain
