Table Info

Table 4.

Omalizumab therapy in patients with EGPA

Reference	Study design	Number of patients	Dose and route of administration	Results
Giavina-Bianchi et al. [66], 2007	Case report	1	300 mg SC every 2 weeks	Improvement of asthma Blood eosinophil reduction
Pabst et al. [67], 2008	Case report	2	Doses adjusted to weight and IgE levels	Blood eosinophil count normalization Immunosuppressive treatment was stopped
Lau et al. [68], 2011	Case report	1	Doses adjusted to weight and IgE levels	Exacerbation when CS was tapered No clinical or radiological improvement
Jachiet et al. [71], 2016	Retrospective multicentre study	17	Doses adjusted to weight and IgE levels	Mild efficacy for treating asthma, ear, nose, and throat (ENT) symptoms CS reduction BVAS improvement Blood eosinophil count did not decrease EGPA flares, possibly due to the reduction in the CS dose
Caruso et al. [70], 2018	Case report	1	450 mg SC every 2 weeks	Lung function improvement ACT and quality of life questionnaire improvement Blood eosinophil counts reduction CS reduction
Celebi Sozener et al. [72], 2018	Retrospective chart review	18	Doses adjusted to weight and IgE levels	10 Patients responded completely CS reduction Exacerbation reduction forced expiratory volume in the first second (FEV1) improvement No decrease in blood eosinophil count

Declarations

Author contributions

ACH: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. CP: Conceptualization, Investigation, Visualization, Writing—review & editing. GP: Validation, Writing—review & editing, Supervision. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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