The authors declare that they have no conflicts of interest.
Ethical approval
The study was approved by the De Montfort University Institutional Review Board Faculty Research Ethics Committee (FREC/019-68) and complies with the Declaration of Helsinki.
Consent to participate
Informed consent to participate in this study was obtained from all participants.
Consent to publication
Not applicable.
Availability of data and materials
The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher. However, data sets will be anonymised to maintain patient confidentiality.
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References
2022 GINA Report, Global Strategy for Asthma Management and Prevention [Internet].Fontana: Global Initiative for Asthma – GINA; c2024 [cited 2024 Aug 26]. Available from: https://ginasthma.org/gina-reports/
Vaswani A, Khaw HJ. Medicine in a minute. Branbury: Scion Publishing Ltd; 2018.
Ebmeier S, Thayabaran D, Braithwaite I, Bénamara C, Weatherall M, Beasley R. Trends in international asthma mortality: analysis of data from the WHO Mortality Database from 46 countries (1993-2012).Lancet. 2017;390:935–45. [DOI] [PubMed]
Aldridge RE, Hancox RJ, Cowant JO, Frampton CM, Town GI, Taylor DR. Eosinophils and eosinophilic cationic protein in induced sputum and blood: effects of budesonide and terbutaline treatment.Ann Allergy Asthma Immunol. 2002;89:492–7. [DOI] [PubMed]
Swystun VA, Gordon JR, Davis EB, Zhang X, Cockcroft DW. Mast cell tryptase release and asthmatic responses to allergen increase with regular use of salbutamol.J Allergy Clin Immunol. 2000;106:57–64. [DOI] [PubMed]
Jorup C, Lythgoe D, Bisgaard H. Budesonide/formoterol maintenance and reliever therapy in adolescent patients with asthma.Eur Respir J. 2018;51:1701688. [DOI] [PubMed]
Rabe KF, Pizzichini E, Ställberg B, Romero S, Balanzat AM, Atienza T, et al. Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma: a randomized, double-blind trial.Chest. 2006;129:246–56. [DOI] [PubMed]
Kuna P, Peters MJ, Manjra AI, Jorup C, Naya IP, Martínez-Jimenez NE, et al. Effect of budesonide/formoterol maintenance and reliever therapy on asthma exacerbations.Int J Clin Pract. 2007;61:725–36. [DOI] [PubMed] [PMC]
Nannini LJ, Neumayer NS, Brandan N, Fernández OM, Flores DM. Asthma-related hospitalizations after implementing SABA-free asthma management with a maintenance and anti-inflammatory reliever regimen.Eur Clin Respir J. 2022;9:2110706. [DOI] [PubMed] [PMC]
Nwaru BI, Ekström M, Hasvold P, Wiklund F, Telg G, Janson C. Overuse of short-acting β2-agonists in asthma is associated with increased risk of exacerbation and mortality: a nationwide cohort study of the global SABINA programme.Eur Respir J. 2020;55:1901872. [DOI] [PubMed] [PMC]
Yorgancıoğlu A, Aksu K, Naycı SA, Ediger D, Mungan D, Gül U, et al.; SABINA Turkey Study Group. Short-acting β2-agonist prescription patterns in patients with asthma in Turkey: results from SABINA III.BMC Pulm Med. 2022;22:216. [DOI] [PubMed] [PMC]
Montero-Arias F, Garcia JCH, Gallego MP, Antila MA, Schonffeldt P, Mattarucco WJ, et al. Over-prescription of short-acting β2-agonists is associated with poor asthma outcomes: results from the Latin American cohort of the SABINA III study.J Asthma. 2023;60:574–87. [DOI] [PubMed]