Table Info

Table 2.

Experimental design for MAE and results for and antioxidant activity

Runs^*	Factors				Responses
Runs^*	X₁	X₂	X₃	X₄	Y₁: TPC mg (GAE/100 g PDCF)	Y₂: FRAP (mg TE/100 g PDCF)	Y₃: ABTS (mg TE/100 g PDCF)
1	50	40	5.0	0.03	991.5 ± 107.6 a	851.3 ± 80.9 c	15,979.5 ± 18.6 a
2^**	60	60	3.5	0.04	1,163.6 ± 112.6 a	789.3 ± 90.3 b	17,668.5 ± 1,323.5 a
3	40	60	3.5	0.04	1,311.1 ± 105.1 b	984.2 c ± 41.7 c	17,709.5 ± 1,172.6 a
4	60	30	3.5	0.04	1,004.8 ± 162.8 a	614.1 ± 22.6 a	16,404.2 ± 1,230.7 a
5	80	60	3.5	0.04	950.2 ± 50.2 a	589.5 ± 14,0 a	16,396.0 ± 708.2 a
6	60	60	1.0	0.04	1,083.5 ± 53.9 a	890.4 ± 13.4 c	18,645.5 ± 2,240.8 a
7	50	80	5.0	0.05	1,199.9 ± 46.1 a	1,345.3 ± 49.8 e	22,738.6 ± 278.6 b
8	70	80	5.0	0.03	1,168.9 ± 83.9 a	783.1 ± 48.0 b	21,467.2 ± 2,461.4 b
9	50	80	2.0	0.03	1,423.7 ± 117.4 b	1,213.6 ± 7.55 d	26,218.0 ± 1,377.8 b
10	70	40	5.0	0.03	1,149.9 ± 72.7 a	1,120.9 ± 57.6 d	17,526.6 ± 232.2 a
11	70	80	2.0	0.05	995.7 ± 21.7 a	1,208.2 ± 0.47 d	16,460.0 ± 885.9 a
12	60	60	3.5	0.02	1,425.1 ± 143.3 b	1,792.2 ± 150.2 f	16,858.5 ± 1,932.0 a
13**	60	60	3.5	0.04	1,064.1 ± 64.2 a	1,079.5 ± 88.8 d	16,127.9 ± 716.8 a
14	60	60	6.0	0.04	1,201.8 ± 63.5 a	942.9 ± 42.9 c	16,918.0 ± 1,378.4 a
15	60	90	3.5	0.04	1,308.8 ± 48.7 b	1,333.2 ± 8.9 e	23,174.1 ± 1,555.1 b
16	50	40	2.0	0.03	1,113.8 ± 104.2 a	751.1 ± 3.9 b	14,877.0 ± 125.2 a
17	70	40	2.0	0.05	988.6 ± 17.3 a	757.7 ± 61.9 b	13,121.2 ± 593.8 a
18	60	60	3.5	0.05	834.5 ± 6.8 a	1,077.3 ± 21.0 d	15,932.4 ± 416.5 a
Y₁ (TPC-MAE) = –22.9608 – 22,057.7 × X₄ + 14.7794 × X₁ + 23.8296 × X₂ + 540.248 × X₃ – 7,640.92 × X₄² + 366.208 × X₄ × X₁ – 70.875 × X₄ × X₂ – 3,602.78 × X₄ × X₃ – 0.00481 × X₁² – 0.31 × X₁ × X₂ – 6.03412 × X₁ × X₃ + 0.0219546 × X₂² – 0.373333 × X₂ × X₃ + 1.67959 × X₃² Y₂ (FRAP-MAE) = –3,479.08 – 167,341 × X₄ + 156.152 × X₁ + 31.1404 × X₂ + 1,518.47 × X₃ + 1.60984E6 × X₄² + 90.7463 × X₄ × X₁ + 512.344 × X₄ × X₂ – 5,395.72 × X₄ × X₃ – 0.681016 × X₁² – 0.527356 × X₁ × X₂ – 16.6156 × X₁ × X₃ – 0.00511725 × X₂² – 3.15329 × X₂ × X₃ – 13.7563 × X₃² Y₃ (ABTS-MAE) = –10,913.2 + 804,789 × X₄ + 423.605 × X₁ + 382.589 × X₂ – 8,219.49 × X₃ – 484,542 × X₄² – 13,930.5 × X₄ × X₁ – 3,239.76 × X₄ × X₂ + 67,615.9 × X₄ × X₃ + 1.83932 × X₁² – 6.76285 × X₁ × X₂ + 79.89 × X₁ × X₃ + 2.87847 × X₂² – 16.583 × X₂ × X₃ + 196.291 × X₃²

^*Derived from a Draper-Lin reduced composite design (16 random orthogonal runs and ^** 2 center points). X₁: ethanol concentration; X₂: temperature; X₃: extraction time; X₄: g PDCF/mL solvent. In each column samples with different letters are statistically different at the level of alpha = 0.05. Equations at the bottom of the table are those of the fitted model based on the regression coefficients for the different responses

Supplementary materials

The supplementary material for this article is available at: https://www.explorationpub.com/uploads/Article/file/101017_sup_1.pdf.

Declarations

Acknowledgments

This research was supported by Secretaría de Ciencia y Tecnología (Universidad Nacional de Córdoba) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). We would like to thank Fernanda Quiroga for her technical help.

Author contributions

MA: Data aquisition, Formal analysis, Methodology, Writing—original draft. CA: Methodology, Writing—original draft. DD and LM: Data acquisition, Methodology. AA: Conceptualization, Study design, Funding acquisition. RB: Conceptualization, Study design, Formal analysis, Funding acquisition, Writing—review & editing.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This research was supported by Secretaría de Ciencia y Tecnología (Universidad Nacional de Córdoba) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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