Summary of laboratory markers (established or candidates) cited in the article, as marker of MetS

MarkerClassVariationTypeEligibleReferences
Waist circumferencePhysicalIncreaseEstablishYesFahed et al. [3], 2022
TGLipidic profileIncreaseEstablishYesFahed et al. [3], 2022
HDL-CLipidic profileDecreaseEstablishYesFahed et al. [3], 2022
Fasting glucoseLipidic profileIncreaseEstablishYesFahed et al. [3], 2022
Blood pressureLipidic profileIncreaseEstablishYesFahed et al. [3], 2022
TG/HDL-CLipidic profileIncreaseCandidateYesZhang et al. [17], 2022
SdLDL-CLipidic profileIncreaseCandidateNoHirano et al. [24], 2022
ApoB/ApoA1Lipidic profileIncreaseCandidateNoReynoso-Villalpando et al. [25], 2019
OMENInflammatory functionDecreaseCandidateNoMakiel et al. [27], 2023
ResistinInflammatory functionIncreaseCandidateNoKim et al. [34], 2022
VisfatinInflammatory functionIncreaseCandidateNoBerezin et al. [29], 2020
Activin-AInflammatory functionIncreaseCandidateYesPeng et al. [42], 2018
Leptin/AdiponectinInflammatory functionIncreaseCandidateYesAdejumo et al. [32], 2019
TNF-αInflammatory functionIncreaseCandidateNoBerezin et al. [29], 2020
IL-6Inflammatory functionIncreaseCandidateNoBerezin et al. [29], 2020
PAI-1Inflammatory functionIncreaseCandidateYesKim et al. [34], 2022
AngIIInflammatory functionIncreaseCandidateNoRagino et al. [35], 2020
NLRP3Inflammatory functionIncreaseCandidateNoLu et al. [39], 2023
TBARS, MDA, 4-HNE, and F2 isoproteinsOxidative stressIncreaseCandidateYesMasenga et al. [13], 2023
Protein carbonyls, advanced glycation, ox-LDL, and advanced oxidation proteinsOxidative stressIncreaseCandidateNoMasenga et al. [13], 2023
8-Oxo-Dg, 5-chlorouracil, and 5-chlorocytosineOxidative stressIncreaseCandidateNoMasenga et al. [13], 2023
Xanthine oxidase, GGT, MPO, NOX, and NOSOxidative stressIncreaseCandidateNoMasenga et al. [13], 2023
Serum ferritinOxidative stressIncreaseCandidateYesMasenga et al. [13], 2023

AngII: angiotensin II; GGT: gamma-glutamyl transferase; HDL-C: high density lipoprotein-cholesterol; IL: interleukin; MDA: malonyldialdehyde; MPO: myeloperoxidase; NLRP3: NOD-like receptor family, pyrine domain containing 3; NOS: nitric oxide synthase; NOX: NADPH oxidase; OMEN: omentin; ox-LDL: oxidized-low-density lipoprotein; PAI-1: plasminogen activator inhibitor-1; SdLDL-C: small dense low-density lipoprotein cholesterol; TBARS: thiobarbituric acid reactive substances; TG: triglycerides; TNF-α: tumor necrosis factor α; 8-oxo-Dg: 8-oxo-2-deoxyguanosine; 4-HNE: 4-hydroxy-2-nonenal; ApoA1: apolipoprotein A1; ApoB: apolipoprotein B