Table Info

Table 3.

Adjusted odds ratios and 95% confidence intervals

Variable	Contrast	Odds ratio (95% confidence interval)	Test statistic
IVSDT (mm)	12:10	1.13 (0.82–1.56)	χ₂² = 3.48, P = 0.176
LVESD (mm)	35:28	1.38 (0.95–2.01)	χ₁² = 2.81, P = 0.094
LVEF (%)	-	-	χ₂² = 8.02, P = 0.018
-	46:61	0.34 (0.16–0.73)	-
-	69:61	1.07 (0.67–1.71)	-
LVPWDT (mm)	12:9	1.35 (0.83–2.20)	χ₁² = 1.43, P = 0.232
Aortic regurgitation	Mild to severe: none or trivial	0.71 (0.39–1.28)	χ₁² = 1.32, P = 0.250
Mitral regurgitation	Mild to severe: none or trivial	0.96 (0.58–1.58)	χ₁² = 0.03, P = 0.868
LVOT velocity (m/s)	-	-	χ₂² = 8.20, P = 0.017
-	0.9:1.1	0.51 (0.32–0.82)	-
-	1.4:1.1	1.20 (0.75–1.91)	-
LV cardiac index [L/(min·m²)]	3.6:2.6	1.05 (0.78–1.43)	χ₁² = 0.11, P = 0.742
MV E:e’	16.7:8.6	1.42 (1.00–2.02)	χ₁² = 3.85, P = 0.050
AVSP velocity (m/s)	1.7:1.2	1.08 (0.84–1.40)	χ₁² = 0.37, P = 0.543

For all continuous variables except LVOT and LVEF, the odds ratios represent an interquartile increase in that variable (i.e., an increase from the 25th to the 75th percentile). For LVOT and LVEF, which appear to be non-monotonically related to the outcome (see Figure 3), odds ratios are calculated at 2 data points compared with the median (i.e., 50th percentile) to represent the effects of having an extremely low value (10th percentile) and an extremely high value (90th percentile). As IVSDT, LVOT, and LVEF each showed evidence of nonlinearity, these variables were modeled with regression splines, and their overall tests of the association are based on 2 degrees of freedom. -: no data. IVSDT: interventricular septum diastolic thickness; LVOT: left ventricular outflow tract; LV: left ventricular; LVESD: left ventricular end-systolic dimension; LVPWDT: left ventricular posterior wall diastolic thickness; MV: mitral valve; AVSP: aortic valve systolic peak; LVEF: left ventricular ejection fraction

Supplementary materials

The supplementary material for this article is available at: https://www.explorationpub.com/uploads/Article/file/101234_sup_1.pdf.

Declarations

Acknowledgments

The authors are extremely grateful for the philanthropic support provided by a gift from Eva and Gene Lane (Baddour LM), which was paramount in our work to advance the science of cardiovascular infections and has been an ongoing focus of investigation at Mayo Clinic for over 60 years.

Author contributions

JAQM: Conceptualization, Data curation, Investigation, Methodology, Writing—original draft, Writing—review & editing. JRH: Data curation, Writing—original draft, Writing—review & editing. HRV: Supervision, Writing—review & editing. BDL: Software, Formal analysis, Validation, Methodology, Writing—original draft, Writing—review & editing. MJD, MHT, JCO, HIM, NSA, PS, and DCD: Supervision, Writing—review & editing. LMB: Conceptualization, Supervision, Investigation, Methodology, Writing—original draft, Writing—review & editing. All authors have read and agreed to the published version of the manuscript.

Conflicts of interest

Larry M. Baddour, M.D. reports over the past 12 months UpToDate, royalty payments (authorship duties). The other authors declare that they have no conflicts of interest.

Ethical approval

This study was approved by the Mayo Clinic Institutional Review Board, the reference number is 20-011665.

Consent to participate

Informed consent to participate was obtained from all subjects involved in the study.

Consent to publication

Not applicable.

Availability of data and materials

The data underlying this article cannot be shared publicly because the privacy of the individuals who participated in the study must be maintained and the data underlying this article were provided by the Mayo Clinic under license and permission. The data will be shared with a reasonable request to the corresponding author (Juan A. Quintero-Martinez) with the permission of the Mayo Clinic.

Funding

Not applicable.

Copyright

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