IC50 values for DOX against MDA-MB-231 and C4-2B cell lines at D3 and D7, with 95% CI
| Cell line | IC50—D3 (µmol/L) | IC50—D7 (µmol/L) |
|---|---|---|
| MDA-MB-231 | 0.14 (95% CI: 0.09, 0.21) | 0.48 (95% CI: 0.41, 0.56) |
| C4-2B | 0.07 (95% CI: 0.05, 0.09) | 0.32 (95% CI: 0.26, 0.40) |
D3: 3 days; D7: 7 days
The authors gratefully acknowledge Professor M. Park (McGill university) for providing donating a cell line used in this study and the support of the McGill Orthopaedic fellows and surgeons of the McGill Scoliosis and Spine Group for their assistance in obtaining primary human osteoblasts.
AS: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing—original draft, Writing—review & editing. MMG and MEC: Investigation, Writing—original draft, Writing—review & editing. MHW and DHR: Conceptualization, Funding acquisition, Project administration, Resources, Writing—review & editing, Supervision. All authors read and approved the submitted version.
The authors declare that they have no conflicts of interest.
Human lumbar vertebral tissues were obtained from donors with institutional ethical approval in collaboration with Transplant Quebec. This study complies with the Declaration of Helsinki.
Informed consent to participate in the study was obtained from all participants.
Not applicable.
The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher.
AO Spine Young Investigator Research Grant Award 2022 [S-16-138W] awarded to DHR and MHW; Cancer Research Society operating grant 2018-2020 given to MHW; AS received the CIHR CGS-M and FRQS doctoral [318974] scholarships; MEC received the CIHR postdoctoral fellowship award [171258]; DHR is a FRQS Junior 2 Research Scholar. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
© The Author(s) 2024.