AMSS values (baseline, 30-week, and change) stratified (< 8 and ≥ 8) by HADS-D and HADS-A values
Patient groups | Baseline AMSS: median (IQR) | 30-week AMSS: median (IQR) | ∆AMSS: median (IQR) |
---|---|---|---|
HADS-D ≥ 8 | |||
P, n = 44 | 45 (39, 54) | 44.5 (36.5, 50) | –3 (–9, 3) |
TU, n = 35 | 50 (42, 55) | 42 (31, 51) | –6 (–11, 1) |
HADS-D < 8 | |||
P, n = 50 | 34 (27, 38) | 31 (26, 41) | –2 (–5, 3) |
TU, n = 41 | 35 (31, 40) | 31(28, 35) | –5 (–7, –1) |
HADS-A ≥ 8 | |||
P, n = 34 | 45 (38, 57) | 44 (31, 53) | –2.5 (–10, 2) |
TU, n = 37 | 47 (40, 54) | 41 (31, 51) | –3 (–10, 2) |
HADS-A < 8 | |||
P, n = 60 | 36 (29.5, 41) | 34.5 (26.5, 42) | –2 (–6, 3) |
TU, n = 39 | 35 (32, 41) | 31 (27, 38) | –6 (–9, –2) |
∆AMSS: changes in ageing male symptom scale; HADS-A: Hospital Anxiety and Depression Scale-anxiety; HADS-D: Hospital Anxiety and Depression Scale-depression; IQR: interquartile range; P: placebo; TU: testosterone undecanoate
We acknowledge the contributions of Drs Nigel Cole, Mithun Bhartia, Jesse Raju, David Kennedy, and Peter Wilkinson for their role in conceiving, designing, data collection, statistical analysis, and preparing the original publications from the BLAST Study dataset. We would also like to thank the Primary Care Practices and the patients who took part in the study.
PR: Conceptualization, Writing—original draft, Writing—review & editing. MZ and CSK: Writing—original draft. JM: Writing—original draft, Visualization. SR: Conceptualization, Writing—original draft, Writing—review & editing, Visualization. GH: Conceptualization, Writing—original draft. All authors have read and agreed to the published version of the manuscript.
The author declares that there are no conflicts of interest.
BLAST study obtained ethics approval from the Multi centre UK Research Ethics Committee (08/H1208/30).
Informed consent to participate in the study was obtained from all participants.
Not applicable.
The datasets that support the findings of this study are available from Professor Sudarshan Ramachandran upon reasonable request.
The practice expenses (BLAST RCT) of the research are supported by a grant from Bayer plc [BSP-SOP-040]. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors did not receive any support from any organization for the submitted work. No funding was received to assist with the preparation of this manuscript.
© The Author(s) 2024.