The association between TU (P: reference) and ∆AMSS (dependent variable) with the models adjusted for baseline AMSS values
| Univariate/multivariate regression analyses outcome: ∆AMSS | Coefficient (95% CI) | p | ||
|---|---|---|---|---|
| Total cohort | Model 1 (n = 170) | TU vs P (reference) | –3.12 (–5.65, –0.61) | p = 0.015 |
| Model 2 (n = 170) | Baseline AMSS | –0.24 (–0.35, –0.13) | p < 0.001 | |
| Model 3 (n = 170) | TU vs P (reference) | –2.66 (–5.07, –0.25) | p = 0.031 | |
| Baseline AMSS | –0.23 (–0.34, –0.12) | p < 0.001 | ||
| HADS-D ≥ 8 | Model 4 (n = 79) | TU vs P (reference) | –4.25 (–8.40, –0.11) | p = 0.044 |
| Baseline AMSS | –0.30 (–0.50, –0.10) | p = 0.003 | ||
| HADS-D < 8 | Model 5 (n = 91) | TU vs P (reference) | –1.15 (–3.94, 1.65) | p = 0.42 |
| Baseline AMSS | –0.22 (–0.41, –0.43) | p = 0.016 | ||
| HADS-A ≥ 8 | Model 6 (n = 71) | TU vs P (reference) | –2.21 (–7.10, 2.67) | p = 0.37 |
| Baseline AMSS | –0.20 (–0.42, 0.014) | p = 0.067 | ||
| HADS-A < 8 | Model 7 (n = 99) | TU vs P (reference) | –3.21 (–5.48, –0.94) | p = 0.006 |
| Baseline AMSS | –0.35 (–0.47, –0.22) | p < 0.001 | ||
| HADS-D: 8–10 | Model 8 (n = 41) | TU vs P (reference) | –5.37 (–10.52, –0.22) | p = 0.041 |
| Baseline AMSS | –0.43 (–0.70, –0.16) | p = 0.003 | ||
| HADS-D: 11–21 | Model 9 (n = 38) | TU vs P (reference) | 1.05 (–4.39, 6.50) | p = 0.70 |
| Baseline AMSS | –0.088 (–0.31, 0.13) | p = 0.43 | ||
The results from models 4 and 5 are at odds with that previously reported by Hackett et al. [13] using this database stratifying the cohort with a HADS-D value of 11 or greater; thus men with no-depression (HADS-D: < 8) and mild depression (HADS-D: 8–10) were grouped together, whilst we used to a HADS-D cut-off of 8 to have as close to even numbers of men in both subgroups. Further analysis shows that TU was significantly associated with ∆AMSS in the men with mild depression (HADS-D: 8–10) with no such association observed in men with HADS-D: 11–21 (moderate and severe depression), this group was not further stratified as there were only 7 men with severe depression (HADS-D: 15–21). p < 0.05 is considered significant. ∆AMSS: changes in ageing male symptom scale; CI: confidence intervals; HADS-A: Hospital Anxiety and Depression Scale-anxiety; HADS-D: Hospital Anxiety and Depression Scale-depression; P: placebo; TU: testosterone undecanoate
