Table Info

Table 2.

Grouping of hyperprolactinemia cases and controls for differential methylation analysis

Comparison NO.	Group control (n)	Group test (n)
1	CTRL (4) CTRL 4, CTRL 12, CTRL 31, CTRL 54	HPRL-all (12) DBN 30, DBN 54, DBN 68, DBN 75, DBN 92, DBN 94, DBN 6, DBN 7, DBN 8, DBN 16, DBN 39, DBN 51
2	CTRL (4) CTRL 4, CTRL 12, CTRL 31, CTRL 54	HPRL-hypomethylated (6) DBN 30, DBN 54, DBN 68, DBN 75, DBN 92, DBN 94
3	CTRL (4) CTRL 4, CTRL 12, CTRL 31, CTRL 54	HPRL-hypermethylated (6) DBN 6, DBN 7, DBN 8, DBN 16, DBN 39, DBN 51
4	HPRL- hypomethylated (6) DBN 30, DBN 54, DBN 68, DBN 75, DBN 92, DBN 94	HPRL-hypermethylated (6) DBN 6, DBN 7, DBN 8, DBN 16, DBN 39, DBN 51
5	CTRL (4) CTRL 4, CTRL 12, CTRL 31, CTRL 54	HPRL-antipsychotics, all hypomethylated (4) DBN 30, DBN 75, DBN 92, DBN 94
6	CTRL (4) CTRL 4, CTRL 12, CTRL 31, CTRL 54	HPRL-idiopathic, hypomethylated (2) DBN 54, DBN 68
7	CTRL (4) CTRL 4, CTRL 12, CTRL 31, CTRL 54	HPRL-idiopathic, hypermethylated (3) DBN 8, DBN 16, DBN 39
8	CTRL (4) CTRL 4, CTRL 12, CTRL 31, CTRL 54	HPRL-pituitary adenoma, all hypermethylated (3) DBN 6, DBN 7, DBN 51
9	HPRL-idiopathic, hypomethylated (2) DBN 54, DBN 68	HPRL-idiopathic, hypermethylated (3) DBN 8, DBN 16, DBN 39

HPRL: hyperprolactinemia patients; CTRL: control (for Table 2 only)

Declarations

Author contributions

AKK: Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing—original draft, Writing—review & editing. AH: Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing—review & editing. MJ: Methodology, Project administration, Resources, Supervision, Validation. JBS: Resources, Supervision, Validation. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Ethical clearance for the study was obtained from the Institute Ethics Committee, AIIMS, New Delhi, India (IESC/T-63/21.01.2015, RT-39/01.04.2015). All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional ethical committee. The study complies with the Declaration of Helsinki.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Informed consent to publication was obtained from relevant participants.

Availability of data and materials

Requests for accessing the datasets should be directed to [Amanpreet Kaur Kalsi, kalsi.amanpreetkaur@gmail.com].

Funding

This work was supported by the Department of Reproductive Biology, AIIMS. AKK was supported by the Council of Scientific & Industrial Research-University Grants Commission (CSIR-UGC) fellowship [23/06/2013(i)EU-V]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright

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