• 62 results in Exploration of Digestive Diseases
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    Mitochondrial ROS, a trigger for mitochondrial dysfunction and inflammasome activation and a therapeutic target in liver diseases
    Mitochondria are essential organelles responsible for intracellular energy production and play crucial roles in cellular metabolism, inflammation, and apoptosis. Reactive oxygen species (ROS) are pr [...] Read more.
    Hala Saeed Jaara, Sandra Torres
    Published: December 10, 2024 Explor Dig Dis. 2024;3:474–503
    DOI: https://doi.org/10.37349/edd.2024.00062
    This article belongs to the special issue Mitochondria and Lipid Signalling in Liver Diseases
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    Times Cited: 0
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    An overview of pathogenesis of metabolic dysfunction-associated steatotic liver disease
    Steatotic liver disease (SLD) has been known for a long time, but our understanding of this disease has remained poor until the past decade. Despite extensive research, our ability to comprehend the [...] Read more.
    Shahid Habib, Andrew Johnson
    Published: November 11, 2024 Explor Dig Dis. 2024;3:459–473
    DOI: https://doi.org/10.37349/edd.2024.00061
    This article belongs to the special issue Cellular and Molecular Targets for NAFLD or MAFLD Treatments and Their Functions in Liver Fibrosis, Cirrhosis, and Cancer
    View:288
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    Times Cited: 0
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    Hepatitis B virus: modes of transmission, immune pathogenesis, and research progress on therapeutic vaccines
    Hepatitis B virus (HBV) infection affects 262 million people worldwide, leading to over 820,000 deaths annually. The reason HBV has been a persistent issue for decades is that it is a non-cytopathic [...] Read more.
    Chunzheng Li ... Xianguang Yang
    Published: October 14, 2024 Explor Dig Dis. 2024;3:443–458
    DOI: https://doi.org/10.37349/edd.2024.00060
    This article belongs to the special issue Viral Hepatitis
    View:651
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    Times Cited: 0
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    Review
    Searching for novel cellular targets for MASLD and HCC within the humble lysosomal cathepsins
    Metabolic-associated steatotic liver disease (MASLD) and its pathological version, metabolic dysfunction-associated steatohepatitis (MASH), are becoming the main leading causes of chronic liver dise [...] Read more.
    Alejandro del Castillo-Cruz ... Anna Moles
    Published: September 10, 2024 Explor Dig Dis. 2024;3:428–442
    DOI: https://doi.org/10.37349/edd.2024.00059
    This article belongs to the special issue Cellular and Molecular Targets for NAFLD or MAFLD Treatments and Their Functions in Liver Fibrosis, Cirrhosis, and Cancer
    View:628
    Download:39
    Times Cited: 0
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    Review
    Helicobacter pylori infection and metabolic syndrome
    The formation of metabolic changes is based on many factors. In particular, the infectious theory of the development of metabolic “breakdowns” has not lost its relevance. In this regard, many sc [...] Read more.
    Natalia V. Baryshnikova ... Alexander N. Suvorov
    View:597
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    Impact of mitochondrial lipid alterations on liver disease mechanisms and progression
    Lipids are intricate biomolecules responsible for the building up of biological membranes. Besides this structural function, they also display crucial roles in signaling, acting as second messengers [...] Read more.
    Laura Fàbrega ... Carmen Garcia-Ruiz
    Published: September 10, 2024 Explor Dig Dis. 2024;3:382–413
    DOI: https://doi.org/10.37349/edd.2024.00057
    This article belongs to the special issue Mitochondria and Lipid Signalling in Liver Diseases
    Open Access
    Review
    Ascites in cirrhotic patients: a comprehensive review
    Ascites is a frequent complication in patients with cirrhosis, associated with a bad prognosis. Ascites is associated with severe complications, such as spontaneous bacterial peritonitis and kidney  [...] Read more.
    Paul Carrier ... Laure Elkrief
    Published: August 26, 2024 Explor Dig Dis. 2024;3:362–381
    DOI: https://doi.org/10.37349/edd.2024.00056
    This article belongs to the special issue Cirrhosis and Its Complications
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    Review
    Liver and spleen stiffness measurement in the prediction of hepatocellular carcinoma in chronic liver disease
    One of the primary complications of cirrhosis and portal hypertension is the occurrence of hepatocellular carcinoma (HCC), which is among the most common malignancies worldwide. There is limited ava [...] Read more.
    Anna Fichera, Mirella Fraquelli
    Published: August 21, 2024 Explor Dig Dis. 2024;3:344–361
    DOI: https://doi.org/10.37349/edd.2024.00055
    This article belongs to the special issue Fibrosis and Hepatobiliary Cancer
    View:442
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    Times Cited: 0
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    Review
    The impact of hepatitis B virus (HBV) splicing on HBV replication and disease progression
    Chronic hepatitis B (CHB) disease caused by persistent infection with hepatitis B virus (HBV) is a global health problem affecting almost 300 million people worldwide, resulting in up to 1 million d [...] Read more.
    Laura C. McCoullough ... Peter A. Revill
    Published: August 07, 2024 Explor Dig Dis. 2024;3:326–343
    DOI: https://doi.org/10.37349/edd.2024.00054
    This article belongs to the special issue Viral Hepatitis
    View:709
    Download:27
    Times Cited: 0
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    Review
    Pulmonary complications of advanced chronic liver diseases: an updated review
    Patients with advanced chronic liver disease can develop specific pulmonary complications related or unrelated to pre-existing lung disease. The three major pulmonary complications in this patient p [...] Read more.
    Thierry Thevenot ... Hilary M. DuBrock
    Published: July 24, 2024 Explor Dig Dis. 2024;3:301–325
    DOI: https://doi.org/10.37349/edd.2024.00053
    This article belongs to the special issue Cirrhosis and Its Complications
    View:677
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    Times Cited: 0
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    Acute decompensation and acute-on-chronic liver failure
    Acute decompensation is defined as the development of ascites, bleeding due to portal hypertension, jaundice, or hepatic encephalopathy in the presence of known or unknown chronic liver disease. Acu [...] Read more.
    Sencan Acar
    Published: July 24, 2024 Explor Dig Dis. 2024;3:275–300
    DOI: https://doi.org/10.37349/edd.2024.00052
    This article belongs to the special issue Cirrhosis and Its Complications
    View:523
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    Times Cited: 0
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    Review
    Liver transplantation consideration and evaluation: a life-saving treatment in acute-on-chronic liver failure
    With the rising prevalence of chronic liver disease worldwide, the incidence and prevalence of acute-on-chronic liver failure (ACLF) are increasing and attribute to higher morbidity, mortality, and  [...] Read more.
    Andrew Johnson, Shahid Habib
    Published: July 23, 2024 Explor Dig Dis. 2024;3:262–274
    DOI: https://doi.org/10.37349/edd.2024.00051
    This article belongs to the special issue Cirrhosis and Its Complications
    View:719
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    Times Cited: 0
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    Perspective
    Transabdominal Gastro-Intestinal UltraSound (GIUS): a visual approach to intestinal pathology
    Transabdominal ultrasound is a valuable diagnostic approach for evaluating the gastrointestinal tract and related disorders. This dynamic examination provides real-time visualization of the digestiv [...] Read more.
    Cristina Felicani ... Pietro Andreone
    Published: July 05, 2024 Explor Dig Dis. 2024;3:241–261
    DOI: https://doi.org/10.37349/edd.2024.00050
    This article belongs to the special issue Advances in Hepato-gastroenterology: Diagnosis, Prognostication, and Disease Stratification
    View:1223
    Download:19
    Times Cited: 0
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    Review
    Key points for the management of hepatitis C in the era of pan-genotypic direct-acting antiviral therapy
    Hepatitis C viral infections present a significant global health challenge, carrying substantial economic implications. These infections manifest in various clinical forms, including acute and chron [...] Read more.
    Hao Xiong, Jinsheng Guo
    Published: June 18, 2024 Explor Dig Dis. 2024;3:226–240
    DOI: https://doi.org/10.37349/edd.2024.00049
    This article belongs to the special issue Viral Hepatitis
    View:945
    Download:27
    Times Cited: 0
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    Review
    Role of cholesterol homeostasis in MASH-driven hepatocellular carcinoma: not just a neutral fat
    Hepatocellular carcinoma (HCC) is the most common type of liver cancer and its death rate is rising faster than that of any other cancer, while we still lack effective treatments. The increasing inc [...] Read more.
    Vicent Ribas
    Published: June 14, 2024 Explor Dig Dis. 2024;3:203–225
    DOI: https://doi.org/10.37349/edd.2024.00048
    This article belongs to the special issue Mitochondria and Lipid Signalling in Liver Diseases
    Open Access
    Original Article
    Development and evaluation of an in-house ELISA based on autochthonous antigens for detecting IgG anti-Helicobacter pylori in Cuban adults
    Aim: This study aimed to develop and evaluate an in-house enzyme-linked immunosorbent assay (ELISA) based on autochthonous antigens to detect immunoglobulin G (IgG) antibodies against Helicobacte [...] Read more.
    Rosabel Corrales ... Rafael Llanes
    View:658
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    Times Cited: 0
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    Review
    Hepatocellular carcinoma surveillance after HBsAg seroclearance
    Hepatitis B surface antigen (HBsAg) seroclearance is considered the functional cure and the optimal treatment endpoint for chronic hepatitis B (CHB). Patients with CHB who cleared HBsAg generally ha [...] Read more.
    Jimmy Che-To Lai ... Terry Cheuk-Fung Yip
    Published: May 11, 2024 Explor Dig Dis. 2024;3:175–189
    DOI: https://doi.org/10.37349/edd.2024.00046
    This article belongs to the special issue Chronic Hepatitis B and C
    View:1847
    Download:54
    Times Cited: 0
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    Review
    Deciphering the cross-talk between miRNA and tight junctions in hepatocellular carcinoma
    The most common type of liver cancer is hepatocellular carcinoma (HCC) causes a lower survival rate even after systemic treatment. Previous studies have shown evidence that various molecular and epi [...] Read more.
    Siva Bala Subramaniyan, Balasubramaniyan Vairappan
    Published: May 11, 2024 Explor Dig Dis. 2024;3:163–174
    DOI: https://doi.org/10.37349/edd.2024.00045
    This article belongs to the special issue Fibrosis and Hepatobiliary Cancer
    View:730
    Download:11
    Times Cited: 0
    Open Access
    Original Article
    Optimization of protocols for blood-derived extracellular vesicles for studies in liver diseases
    Aim: Extracellular vesicles (EVs) have gained significant attention for their diagnostic and therapeutic potential in various diseases, including liver disorders. This study focuses on optimizing [...] Read more.
    Magnolia Martínez-Aguilar ... Han Moshage
    View:1437
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    Times Cited: 0
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    Review
    Helicobacter pylori and gastric cancer: a critical approach to who really needs eradication
    It is generally accepted that eradication of Helicobacter pylori (H. pylori) infection may reduce the risk of the development of gastric cancer. Recommendations for global generalized tests and trea [...] Read more.
    Elias Kouroumalis ... Argyro Voumvouraki
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