Exploration of Emerging Treatments for Neurotrauma
Brandon Lucke-Wold E-Mail
Department of Neurosurgery, University of Florida, Gainesville, Florida, USA
Research Keywords: neurotrauma, neurosurgery, neuroscience
Mohammad-Reza Hosseini-Siyanaki E-Mail
Department of Neurosurgery, University of Florida, Gainesville, Florida, USA
Research Keywords: Neurosurgery, Neuroscience, Brain Cancer
Zahra Hasanpour Segherlou E-Mail
Department of Neurosurgery, University of Florida, Gainesville, Florida, USA
Research Keywords: Neurosurgery, Neuroscience, Subarachnoid hemorrhage
The special issue “Exploration of Emerging Treatments for Neurotrauma” aims to provide an opportunity for subscribers and readers to dive deep into this subject. Traumatic brain injury (TBI) is a leading cause of mortality and morbidity in patients with trauma. TBI accounts for more than 30% of traumatic injury deaths in the United States. According to studies in this field, secondary injury plays a major role in pathophysiology and clinical outcome. Excitotoxicity leads to cell death and energy depletion at the onset, neuroinflammation at the intermediate stage, and seizures/epilepsy at the late stage. Following the primary brain injury, evidence-based monitoring techniques can help guide the implementation of essential interventions to minimize secondary injury. Nevertheless, there is a great deal of variation in TBI treatment protocols due to injury variability and lack of mechanistic understanding, as well as strong recommendations for treatment. Researchers are hopeful that future research in this field will result in better outcomes for patients with TBI. We invite the journal readers to submit their results on experimental and clinical observations, as well as reviews of the literature. There is no restriction on the length of the papers. Full experimental and methodological details, as applicable, must be provided.
Keywords: traumatic brain injury, emerging treatments,neurotrauma, secondary injury, , neuroinflammation, calcium-channel antagonists, glutamate antagonist, dysbiosis