Many people dread the 'C' word because cancer is often associated with suffering and death. How can healthcare professionals work effectively while achieving job satisfaction and supporting patients and their families? Similarly, caregivers are also at risk of burnout, much like health care providers, as many cancer patients now experience extended survival times, thanks to significant medical advances. The guest editor, Professor Patricia Tai, extends a helpful hand to those burdened with great challenges by offering practical tips, drawn from her nearly 40 years of experience, that are easy to understand and follow. She has carefully observed healthcare systems in Canada and Hong Kong, China. She graciously brought together international experts from various medical fields to contribute to this special issue—a collaborative endeavor dedicated to our courageous patients and caregivers who fight their battles every day.