Characteristics of the study
| Item | Year | Authors | Link | Country | Journal | IF | Cohort data | Sample collection time |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020 | Lu et al. [20] | https://www.webofscience.com/wos/woscc/full-record/WOS:000515868500001 | China | Frontiers in Neuroscience | 4.67 | Samples were matched for demographic and vascular risk factors as well as the history of previous use of anti-platelet medications. The study included 16 patients (M), with an age mean ± SD of 55.4 years ± 12.3 years in the stroke group and 54.11 years ± 10.1 years in the C. | 60 min to 280 min, with a mean time of 179 min from stroke symptoms onset. |
| 2 | 2020 | Ostolaza et al. [23] | https://www.webofscience.com/wos/woscc/full-record/WOS:000520976200005 | Spain | Cell and Bioscience | 7.13 | A cohort of 700 patients recruited from January 2015 to December 2016, 30 patients (19 M + 11 F) were included in the discovery cohort and 50 patients were included in the validation cohort. The age of patients in the discovery cohort was between 49 and 80. No healthy C. | Venous blood samples were drawn from acute stroke patients within 24 h after admission. |
| 3 | 2020 | Abe et al. [24] | https://pubmed.ncbi.nlm.nih.gov/32354168/ | Japan | International Journal of Molecular Sciences | 5.92 | The study included 45 patients (IS: 17 M + 6 F; C: 17 M + 5 F). Patients’ age (IS: 68.6 years ± 15.8 years; C: 69.2 years ± 16.4 years). | Blood samples were collected after the treatment. |
| 4 | 2018 | Vijayan et al. [26] | https://www.webofscience.com/wos/woscc/full-record/WOS:000438578900007 | USA | Human Molecular Genetics | 4.54 | The study included 45 patients (IS: 13 M + 21 F; C: 5 M + 6 F). Patients’ age (IS: 62.88 years ± 11.94 years; C: 62.63 years ± 6.6 years). | Not specified. |
| 5 | 2017 | Mick et al. [28] | https://www.webofscience.com/wos/woscc/full-record/WOS:000398207000017 | USA | Stroke | 6.33 | The study included 2,763 patients (IS: 1,264 M + 1,499 F). Age of patients: 66.3 years ± 8.9 years. No healthy C. | The blood samples were collected at the 8th exam from the patients that were included in Framingham Heart Study (FHS) off-spring cohort. |
| 6 | 2019 | Zhu et al. [29] | https://www.webofscience.com/wos/woscc/full-record/WOS:000457370300001 | China | Frontiers in Neurology | 3.55 | The study included 10 patients (IS: 4 M + 1 F; C: 4 M + 1 F). Patients’ age (IS: 61 years ± 11.3 years; C: 59 years ± 6.2 years). | Blood was collected within 24 h and 7 days after symptom onset. |
| 7 | 2020 | Cao et al. [31] | https://www.webofscience.com/wos/woscc/full-record/WOS:000513554900005 | China | International Journal of Molecular Medicine | 3.09 | Patients with IS had only one episode of stroke ≥ 6 months before blood collection, and controls could not have a family history of stroke. The study included 40 patients (IS: 10 M + 10 F; C: 10 M + 10 F). Patients’ age (IS: 60.2 years ± 10.6 years; C: 58.7 years ± 11.0 years). | The IS patients in the study suffered only one stroke episode ≥ 6 months before the blood collection. |
| 8 | 2022 | Wang et al. [33] | https://www.webofscience.com/wos/woscc/full-record/WOS:000711301400001 | China | Genes & Genomics | 1.83 | The study included 6 patients (IS: 3 M; C: 3 M). Patients’ age (IS: 51 years ± 0.81 years; C: 51.3 years ± 0.47 years). | Peripheral blood samples were collected the next morning after a fasting period of 10 h or overnight. |
| 9 | 2020 | Zhang et al. [38] | https://www.webofscience.com/wos/woscc/full-record/WOS:000575004300053 | China | Molecular Medicine Reports | 2.95 | The study included 168 patients divided into a stroke group and a non-stroke C. Patients’ age and sex are not specified. | Not specified. |
| 10 | 2020 | Zhu et al. [40] | https://www.webofscience.com/wos/woscc/full-record/WOS:000519997800015 | China | Genomics | 5.73 | The study included 610 patients (IS: 422 M + 188 F). Patients’ age (≤ 55 years old: 172; ≥ 55 years old: 438). No healthy C. | Samples were collected at the onset of IS. |
| 11 | 2018 | Li et al. [44] | https://www.webofscience.com/wos/woscc/full-record/WOS:000429737400001 | China | Lipids in Health and Disease | 0.95 | The study included 747 patients divided into an IS group and a non-stroke C. Patients’ age and sex are not specified. | Not specified. |
| 12 | 2020 | Xie et al. [45] | https://www.webofscience.com/wos/woscc/full-record/WOS:000601211900010 | China | Biomed Research International | 3.41 | The study included 34 patients (IS: 14 M + 20 F). Patients’ age: 71.94 years ± 14.61 years. No healthy C. | Samples were collected within 24 h from the known onset of symptoms and again at 24–48 h after onset. |
| 13 | 2019 | Shroff et al. [47] | https://www.webofscience.com/wos/woscc/full-record/WOS:000455396400002 | USA | Translational Stroke Research | 5.78 | The study included 155 patients (IS: 30 M + 13 F; C: 59 M + 53 F). Patients’ age (IS: 65.48 years ± 3.72 years; C: 63.83 years ± 2.41 years). | Venous blood draws were performed within 24 h of stroke onset. |
| 14 | 2017 | Williams et al. [48] | https://pubmed.ncbi.nlm.nih.gov/28495826/ | USA | Stroke | 6.33 | The study included 2,100 patients (IS: 1,335 M + 765 F). Patients’ age: 68.5 years ± 11.48 years. No healthy C. | Not specified. |
| 15 | 2021 | Davis Armstrong et al. [49] | https://pubmed.ncbi.nlm.nih.gov/33661917/ | USA | Plos One | 3.58 | The study included 44 patients (IS: 22 M + 22 F). Patients’ age: 63.56 years ± 10.59 years. No healthy C. | Participants were enrolled within 120 days of suffering a non-disabling cerebral infarction and followed for two years. |
| 16 | 2021 | Davis Armstrong et al. [51] | https://pubmed.ncbi.nlm.nih.gov/34252155/ | USA | Plos One | 3.58 | The study included 180 patients (IS: 103 M + 77 F). Patients’ age: 65.89 years ± 11.18 years. No healthy C. | Participants were enrolled within 120 days of suffering a non-disabling cerebral infarction and followed for two years. |
| 17 | 2018 | Soriano-Tárraga et al. [59] | https://pubmed.ncbi.nlm.nih.gov/29515201/ | Spain | Scientific Reports | 4.01 | The study included 594 patients (IS: 326 M + 268 F). Patients’ age: 76 (64–85) years. No healthy C. | DNA samples were extracted from whole peripheral blood collected in the acute phase of the stroke. |
| 18 | 2021 | Miao et al. [64] | https://www.webofscience.com/wos/woscc/full-record/WOS:000685052900002 | China | Neuropsychiatric Disease and Treatment | 0.77 | The study included 112 patients (IS: 58 M + 26 F; C: 13 M + 15 F). Patients’ age (IS: 61.94 years ± 8.03 years; C: 57.64 years ± 9.0 years). | Not specified. |
| 19 | 2019 | Sikora et al. [65] | https://www.webofscience.com/wos/woscc/full-record/WOS:000473756000246 | Poland | International Journal of Molecular Sciences | 4.55 | The study included 68 patients (37 M + 31 F). Patients’ age: 67.5 years ± 12.4 years. No healthy C. | Blood was drawn immediately after arrival at the hospital. |
| 20 | 2018 | Tufekci et al. [66] | https://www.webofscience.com/wos/woscc/full-record/WOS:000426733300001 | Turkey | Frontiers in Neurology | 3.55 | The study included 190 patients (IS: 57 M + 38 F; C: 47 M + 48 F). Patients’ age (IS: 69.65 years ± 8.12 years; C: 67.35 years ± 10.13 years). | Within 24 h after stroke onset followed by the 1st week, the 1st month, and the 6th month. |
| 21 | 2021 | Li et al. [68] | https://pubmed.ncbi.nlm.nih.gov/34188129/ | Japan | Scientific Reports | 4.54 | The study included 633 patients (IS: 253 M + 211 F; C: 105 M + 64 F). Patients’ age (IS: 70.12 years ± 10.90 years; C: 58.7 years ± 15.46 years). | Serum samples associated with it were obtained within 2 weeks after onset. |
M: male; F: female; C: control group (applicable to Table 1 only)
