Exploration of BioMat-X

Special Issue Topic

Nature-Based Biomaterials for Biomedical Applications

Submission Deadline: March 31, 2025

Guest Editor

Jayachandran Venkatesan E-Mail

Assistant Professor at Yenepoya Research Centre, Yenepoya University, Mangalore, India.

Research Keywords: biomaterials; tissue engineering; drug delivery; alginate; chitosan

About the Special Issue

Natural-based biomaterials have gained significant attention from researchers and clinicians for therapeutic applications due to bioactivity and biocompatibility. Various proteins, polysaccharides, and ceramics materials from seaweed, plants, and crustaceans have been extensively studied for tissue engineering, drug delivery, and biosensor applications. Bone graft substitutes, heart stunt, and skin graft materials from natural substances are clinically translated and commercialized. We wish to bring recent and advanced technologies on natural-based biomaterials for clinical applications in the current special issue. The special issue will cover various materials and applications, including:
★ Alginate
★ Carrageenan
★ Cellulose
★ Collagen
★ Chitosan
★ Fucoidan
★ Gelatin
★ Hydroxyapatite
★ Ulvan
★ Silk Fibroin
★ Tissue engineering
★ Drug delivery
★ Biosensor

Keywords: antimicrobials; biosensors; cancer; drug delivery; tissue engineering

Call for Papers

Published Articles

Open Access

Original Article

Fabrication and characterization of pHEMA hydrogel conduit containing GelMA-HaMA IPN for peripheral nerve regeneration
Aim: Small defects after any injury to the periperal nerves results in self-regeneration. However, for larger defects, suturing or grafting are necessary, which may have limitations. Thus, resear [...] Read more.

Aim:

Small defects after any injury to the periperal nerves results in self-regeneration. However, for larger defects, suturing or grafting are necessary, which may have limitations. Thus, research on nerve guidence conduits is needed without drawbacks. The aim of the study was to develop hydrogel-based conduits containing interpenetrating network (IPN).

Methods:

Methacrylated gelatin (GelMA)-methacrylated hyaluronic acid (HaMA) IPN was filled the poly(2-hydroxyethylmethacrylate) (pHEMA) the outer conduit. Schwann cells (SCs) were used on the pHEMA and the distal end of the tube was injected with netrin-1 to support model SH-SY5Y cells.

Results:

¹H-nuclear magnetic resonance (¹H-NMR) showed that methacrylation degrees were 94% ± 2% for GelMA and 60% ± 7% for HaMA. The fraction of HaMA increased the degradation rate; pure HaMA degraded in 3 weeks, while pure GelMA in more than 5 weeks. An increase in the fraction of 2-hydroxyethylmethacrylate (HEMA) from 20% to 56% decreased the porosity and the pore size, significantly. SH-SY5Y cells migrated along the conduit in the presence of netrin-1. NeuN expression was increased in 2 weeks indicating neuronal activity.

Conclusions:

SH-SY5Y cells produced neurites in the IPN. pHEMA conduit including GelMA-HaMA IPN is a good candidate for peripheral nerve regeneration applications. As future studies, the conduit will be tested in vivo for nerve regeneration.

Damla Arslantunali Sahin ... Vasif Hasirci

Published: February 26, 2024 Explor BioMat-X. 2024;1:34–57
DOI: https://doi.org/10.37349/ebmx.2024.00005

Full Text

PDF

View:2737

Download:143

Times Cited: 1

Aim:

Small defects after any injury to the periperal nerves results in self-regeneration. However, for larger defects, suturing or grafting are necessary, which may have limitations. Thus, research on nerve guidence conduits is needed without drawbacks. The aim of the study was to develop hydrogel-based conduits containing interpenetrating network (IPN).

Methods:

Methacrylated gelatin (GelMA)-methacrylated hyaluronic acid (HaMA) IPN was filled the poly(2-hydroxyethylmethacrylate) (pHEMA) the outer conduit. Schwann cells (SCs) were used on the pHEMA and the distal end of the tube was injected with netrin-1 to support model SH-SY5Y cells.

Results:

¹H-nuclear magnetic resonance (¹H-NMR) showed that methacrylation degrees were 94% ± 2% for GelMA and 60% ± 7% for HaMA. The fraction of HaMA increased the degradation rate; pure HaMA degraded in 3 weeks, while pure GelMA in more than 5 weeks. An increase in the fraction of 2-hydroxyethylmethacrylate (HEMA) from 20% to 56% decreased the porosity and the pore size, significantly. SH-SY5Y cells migrated along the conduit in the presence of netrin-1. NeuN expression was increased in 2 weeks indicating neuronal activity.

Conclusions:

SH-SY5Y cells produced neurites in the IPN. pHEMA conduit including GelMA-HaMA IPN is a good candidate for peripheral nerve regeneration applications. As future studies, the conduit will be tested in vivo for nerve regeneration.

Guest Editor

About the Special Issue

Call for Papers

Published Articles

Aim:

Methods:

Results:

Conclusions:

Aim:

Methods:

Results:

Conclusions: